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    Dvago

    Acyclovir 500Mg Injection 1Vialx10ml

    Per pc

    Rs. 1376.09

    Rs. 1448.52

    |

    QUICK DELIVERY

    How it works

    The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidinen kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in three ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.

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