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      agoviz tablets 25mg (1 box = 2 strips) (1 strip = 7 tablets) Product Image

      Agoviz Tablets 25Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)

      Rs. 682.36

      Rs. 718.20

      |

      QUICK DELIVERY

      Agoviz Tablets Specification

      Requires Prescription (YES/NO)

      Yes

      Generics

      Agomelatine

      Used For

      Depression

      How it works

      Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist. Binding studies indicate that agomelatine has no effect on monoamine uptake and no affinity for a, ß adrenergic, histaminergic, cholinergic, dopaminergic and benzodiazepine receptors. Agomelatine resynchronizes circadian rhythms in circadian rhythm disruption. Agomelatine increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin .

      Agoviz Tablets Usage And Safety

      Dosage

      Agomelatine

      Side Effects

      Psychiatric disorders Common: Anxiety Uncommon: Agitation and related symptoms (such as irritability and restlessness), Aggression Nightmares, Abnormal dreams, confusional state Rare: Mania/hypomania, Hallucinations Frequency not known: Suicidal thoughts or behavior Nervous system disorders Common: Headache, Dizziness, Somnolence, Insomnia, Migraine Uncommon: Paraesthesia, Restless leg syndrome Rare: Akathisia Eyes disorders Uncommon: Blurred vision Ear and vestibular system disorders Uncommon: Tinnitus Gastrointestinal Disorders Common: Nausea, Diarrhoea, Constipation, Abdominal pain, vomiting Hepato- biliary disorders Common: Increased ALAT and/or ASAT Rare: Hepatitis, Increased gamma-glutamyltransferase (GGT) (>3 times the upper limit of the normal range), Increased alkaline phosphatase (>3 times the upper limit of the normal range), Hepatic failure Jaundice Skin and subcutaneous tissue disorders Common: Hyperhidrosis Uncommon: Eczema, Pruritus, Urticaria Rare: Erythematous rash, Face edema and angioedema Musculoskeletal and connective tissue disorders Common: Back pain General disorders and administration site conditions Common: Fatigue Renal and Urinary disorders Rare: Urinary retention

      Drug Interactions

      Potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin , moderate CYP1A2 inhibitors (e.g. propranolol, enoxacin ) .

      Indication

      Treatment of major depressive disorder in adults including prevention of relapse.

      When not to Use

      • Hypersensitivity to Agomelatine • Hepatic impairment (i.e. cirrhosis or active liver disease) or transaminases exceeding 3 times the upper limit of normal. • Concomitant use of potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin)

      Agoviz Tablets Precautions

      Precaution

      Caution should be exercised when prescribing Agomelatine with moderate CYP1A2 inhibitors (e.g. propranolol, enoxacin) which may result in increased exposure of agomelatine.

      Agoviz Tablets Warnings

      Warning 1

      Agomelatine should not be used for the treatment of major depressive episodes in elderly patients with dementia since the safety and efficacy of Agomelatine have not been established in these patients.

      Warning 2

      Agomelatine should be used with caution in patients with a history of bipolar disorder, mania or hypomania and should be discontinued if a patient develops manic symptoms.

      Warning 3

      Depression is associated with an increased risk of suicidal thoughts, self-harm and suicide (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase in the early stages of recovery .

      Agoviz Tablets Additional Information

      Pregnancy category

      Always consult your physician before using any medicine.

      Storage (YES/NO)

      Store this medicine at room temperature, away from direct light and heat.

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