Basoquin 150Mg Tablets 600S (Pack Size 60 X 10S)
Brand : pfizer laboratories
How it works
Amodiaquine is a Mannich base 4-aminoquinoline that is similar in structure and mechanism of action to chloroquine. Amodiaquine is converted to its active metabolite desethylamodiaquine and is thought to act by accumulating inside the parasite food vacuole and interfering with haem detoxification. The drug also inhibits the glutathione-dependent destruction of ferriprotoporphyrin IX in the malaria parasite, resulting in the accumulation of this peptide, which is toxic for the parasite. Amodiaquine is effective against some parasite strains that are resistant to chloroquine, although some crossresistance exists .
BASOQUIN TAB 150 MG 60X10'S
Requires Prescription (YES/NO)
Amodiaquine (AQ) in combination with artesunate is indicated for the treatment of uncomplicated P. falciparum or P. vivax malaria and is considered to be effective against P. ovale, P. knowlesi and P. malariae.
Abdominal discomfort, nausea, vomiting, headache, dizziness, blurring of vision, mental and physical weakness, and fatigue , itching, cardiovascular abnormalities, dyskinesia, ocular damage, neuromuscular disorders and hearing loss .
When not to Use
Amodiaquine should not be prescribed in the following conditions: Hypersensitivity to 4-aminoquinoline derivative. Hepatotoxicity; as amodiaquine may concentrate in the liver, the drug should be used with caution in patients with hepatic disease or alcoholism, and in patients receiving hepatotoxic drugs. It is contraindicated in patients with Liver Disease, Neutropenia and Retinopathy .
Adults : In partially immune subject: Four tablets (600 mg) as a single dose. In non-immune subject: Four tablets (600 mg) as a single dose on each of three successive days. Children : Upto 1 yr, 50mg; 1-4yr , 50-500mg; 5-8 yr 150-200mg ,-12 yr , 200-300mg . All once a wk .OR As directed by your physician.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Caution should be exercised in patients with G6pD deficiency, nerve disease, any allergy, kidney or liver impairment, during pregnancy and breastfeeding .
Avoid long-term use of this medication; otherwise vision loss may occur.
As amodiaquine may concentrate in liver, the drug should be used with caution in patients with hepatic disease and patient receiving hepatotoxic drugs.
Serum ALT levels should be measured in every patient taking the drug who has asthenia and vomiting.
Always consult your physician before using any medicine.
Increased plasma concentration and elevated liver enzyme activities when given in combination with efavirenz ; Decreased plasma concentration with nevirapine ; Increased risk for neutropenia with zidovudine-containing regimens and trimethoprim plus sulfamethoxazole ; Increased risk for cardiac events with anti-arrhythmic agents ; Visual loss or disturbances with mefloquine ; Recommended to use with caution with inhibitors of CYP2C8 and CYP2A6 ; Amodiaquine may inhibit CYP2D6 and CYP2C9.
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