Feldene Capsules 10Mg

Brand : pfizer laboratories

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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Piroxicam

Used For

Pain & Inflammation

How it works

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It works by preventing the production of endogenous prostaglandins. These prostaglandins are responsible for the induction of pain.

USAGE AND SAFETY

Dosage

Piroxicam

Side Effects

Very common: Nausea, epigastric distress, abdominal pain and discomfort, flatulence, constipation and diarrhea. Other possible reactions are hypersensitivity signs, such as skin rash, headache, vertigo, asthenia, blood chemistry modifications, and increase in blood urea. Less common: Vomiting, allergic oedema of the face and hands, blurred vision, tinnitus, aplastic anaemia, leucopoenia, eosinophilia, pancytopenia, thrombocytopenia, increase in parameters of liver functions, jaundice, acute renal insufficiency, water retention that may occur in the form of edema (mainly ankle edema), or cardiocirculatory disorders hypertension, congestive heart failure). Sporadic cases of gastric ulcer with perforation, Stevens-Johnson's syndrome, Lyell’s syndrome-, agranulocytosis, bladder disorders, shock and warning symptoms, acute heart failure. Stomatitis, alopecia and nail growth disorders have been reported. Rare: Gastric ulcers and hemorrhages may also occur.

Drug Interactions

Warfarin , Protein bound drugs , Methotrexate , Aspirin and other NSAIDs , Plasma lithium concentrations , Diuretics , Anti-hypertensives , Cardiac Glycosides , Quinolone Antibiotics , Mifepristone , Cyclosporine , Aminoglycosides , Oral Hypoglycemic Agents.

Indication

It is indicated for a variety of acute painful conditions requiring anti-inflammatory and analgesic activity, including rheumatoid arthritis, osteo-arthritis (arthrosis, degenerative joint disease), ankylosing spondylitis, musculoskeletal and joint disorders, gout, in soft-tissue disorders and in post-operative pain.

When not to Use

Piroxicam should not be used in the following: Known hypersensitivity to the drug. Gastroduodenal ulcer, gastritis, dyspepsia, severe hepatic or renal disturbances, severe heart failure, severe hypertension, severe blood alterations or hemorrhagic diathesis. Piroxicam must not be administered to patients in whom acetylsalicylic acid or other NSAIDs induce the symptoms of asthma, rhinitis or urticaria. Ascertained or suspected pregnancy, during lactation and in children.

PRECAUTIONS

Precaution

Piroxicam should be used with caution in patients with asthma because bronchial smooth muscle spasm may be aggravated by prostaglandin inhibition.

WARNINGS

Warning 1

NSAIDs inhibit the synthesis of renal prostaglandin which plays a supportive role in the maintenance of renal perfusion in patients whose renal blood flow and blood volume are decreased.

Warning 2

Serious gastrointestinal toxicity such as bleeding, ulceration and perforation can occur anytime with or without warning symptoms, in patients treated chronically with NSAID therapy. Piroxicam must be used under strict medical control in patients with a medical history of disturbances in the upper gastrointestinal tract.

Warning 3

As with other NSAIDs, piroxicam should be given under close supervision to patients with hypertension as the antihypertensive effect of thiazide diuretics and -blocking agents is antagonized by NSAIDs.