Fosamax Tablets 70Mg
Brand : obs pakistan pvt. ltd
Requires Prescription (YES/NO)
How it works
At the cellular level, alendronate shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. While incorporated in bone matrix, alendronate is not pharmacologically active. Thus, alendronate must be continuously administered to suppress osteoclasts on newly formed resorption surfaces.
USAGE AND SAFETY
Body as a Whole:Common: Hypersensitivity reactions including urticaria, transient symptoms of myalgia and malaise. Rare: Angioedema, fever, symptomatic hypocalcemia. Gastrointestinal: Common: Esophagitis, esophageal erosions, esophageal ulcers. Rare: Esophageal stricture or perforation and oropharyngeal ulceration. Gastric or duodenal ulcers, some severe and with complications, have also been reported.Skin: Common: Rash (occasionally with photosensitivity), pruritis. Rare: Severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.Special Senses: Rare: Uveitis, scleritis.
Estrogen/Hormone Replacement Therapy (HRT) , Calcium Supplements/Antacids , Aspirin , Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Alendronate sodium is indicated: In postmenopausal women for the treatment of osteoporosis to prevent fractures, including those of the hip and spine (vertebral compression fractures). In postmenopausal women who are at risk of developing osteoporosis. For the treatment of osteoporosis in men to prevent fractures. For the treatment and prevention of glucocorticoid-induced osteoporosis in men and women.For the treatment of Paget’s disease of bone in men and women.
When not to Use
– Hypersensitivity to any component of this product.– Abnormalities of the esophagus which delay esophageal emptying such as stricture or achalasia.– Inability to stand or sit upright for at least 30 minutes.– Hypocalcemia.
Ensuring adequate calcium absorption and vitamin D intake is especially important in patients with Paget’s disease of bone and in patients receiving glucocorticoids as small asymptomatic decreases in serum calcium and phosphate may occur with the treatment of alendronate.
Causes of osteoporosis other than estrogen deficiency, aging and glucocorticoid use should be considered.
Physicians should be alert to symptoms signaling a possible esophageal reaction including dysphasia, odynophagia, retrosternal pain or new/worsening heartburn. Patients should be instructed to discontinue alendronate.
Alendronate is not recommended for patients with severe renal insufficiency (creatinine clearance ).
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.