Dvago Logo
    location icon

    Dvago Logo

    Delivers in

      location icon


      Hilvel Tablets 400Mg+100Mg

      Rs. 10,000.00



      Hilvel Tablets Specification

      Requires Prescription (YES/NO)



      Sofosbuvir + Velpatasvir

      Used For


      How it works

      Sofosbuvir: Sofosbuvir is a pan-genotypic inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. Velpatasvir: Velpatasvir is a HCV inhibitor targeting the HCV NS5A protein, which is essential for both RNA replication and the assembly of HCV virions. Resistance selection in cell culture and cross-resistance studies indicate velpatasvir targets NS5A as its mode of action.

      Hilvel Tablets Usage And Safety


      Sofosbuvir + Velpatasvir

      Side Effects

      The most common adverse reactions (incidence greater than or equal to 10%, all grades) observed with treatment with sofosbuvir + velpatasvir for 12 weeks are headache, fatigue, nausea, nasopharyngitis, insomnia, diarrhea, asthenia, cough, back pain and arthralgia.

      Drug Interactions

      Antacids (e.g., aluminum and magnesium hydroxide) , H2 - receptor antagonists (e.g., famotidine) , Proton-pump inhibitors (e.g., omeprazole) , amiodarone , Digoxin , topotecan , carbamazepine , phenytoin , phenobarbital , oxcarbazepine , rifabutin rifampin , rifapentine , Efavirenz , Tipranavir / ritonavir , St. John’s wort (Hypericum perforatum) , rosuvastatin , atorvastatin.


      Sofosbuvir + Velpatasvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6: - Without cirrhosis or with compensated cirrhosis. - With decompensated cirrhosis for use in combination with ribavirin .

      When not to Use

      Sofosbuvir + velpatasvir is contraindicated in patients with known hypersensitivity to sofosbuvir or to velpatasvir or to any excipient of the product. - Sofosbuvir + velpatasvir and ribavirin combination regimen is contraindicated in patients for whom ribavirin is contraindicated. - Sofosbuvir + velpatasvir should not be administered concurrently with other medicinal products containing any of the same active components.

      Hilvel Tablets Precautions


      Serious symptomatic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta blockers or those with underlying cardiac comorbidities and/or advanced liver disease. Co-administration of amiodarone with sofosbuvir + velpatasvir is not recommended. In patients without alternative viable treatment options, cardiac monitoring is recommended.

      Hilvel Tablets Warnings

      Warning 1

      Test all patients for evidence of current or prior HBV infection by measuring HBsAg and anti-HBc before initiating HCV treatment with sofosbuvir + velpatasvir. In patients with serologic evidence of HBV infection, monitor for clinical and laboratory signs of hepatitis flare or HBV reactivation during HCV treatment with sofosbuvir + velpatasvir and during post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated.

      Warning 2

      If sofosbuvir + velpatasvir is administered with ribavirin, the warnings and precautions for ribavirin apply to this combination regimen.

      Warning 3

      Direct acting anti-viral have been associated with hepatitis B virus (HBV) reactivation in patients who have a current or previous infection with HBV and are treated with certain Direct-Acting Antiviral (DAA) medicines for hepatitis C virus. Health Care Professionals should screen all patients for evidence of current or prior HBV infection before starting treatment with DAAs and monitor patients through blood tests for HBV flare-ups or reactivation during treatment and post-treatment follow-up .

      Hilvel Tablets Additional Information

      Pregnancy category

      Always consult your physician before using any medicine.

      Storage (YES/NO)

      Store this medicine at room temperature, away from direct light and heat.

      Related Products