Indibro Dpi 110/50Mcg Capsules 30S

Brand : martin dow

Rs. 2,850.00

Rs. 3,000.00

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Indibro Dpi Specification

Requires Prescription (YES/NO)

Yes

Generics

Indacaterol maleate , Glycopyrronium

Used For

Chronic Obstructive Pulmonary Disease

How it works

Indacaterol is a selective beta2-adrenergic agonist. Its pharmacological effects are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3’, 5’-adenosine monophosphate (cAMP). In the lung, increased cAMP levels cause relaxation of bronchial smooth muscle, resulting in bronchodilation. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the human heart, there are also beta2- adrenergic receptors in the human heart comprising 10% to 50% of the total adrenergic receptors. The precise function of beta2-adrenergic receptors in the heart is unclear, but their presence raises the possibility that even highly selective beta2-adrenergic agonists may have cardiac effects. Glycopyrronium is an inhaled long-acting muscarinic receptor antagonist (anticholinergic) for once-daily maintenance bronchodilator treatment of COPD. Parasympathetic nerves are the major bronchoconstrictive neural pathway in airways, and cholinergic tone is the key reversible component of airflow obstruction in COPD. Glycopyrronium works by blocking the bronchoconstrictor action of acetylcholine on airway smooth muscle cells, thereby dilating the airways.

Indibro Dpi Usage And Safety

Dosage

Indacaterol maleate , Glycopyrronium

Side Effects

Difficulty breathing or swallowing , swelling of tongue/lips/face , urticaria , skin rash , feeling tired or very thirsty , having an increased appetite without gaining weight , frequent urination , blocked nose , sneezing , cough , headache with or without fever , sore throat , dental caries , chest , stomach upset/indigestion .

Drug Interactions

Aclidinium , anticholinergic agents , long acting beta-2 agonists , nonselective beta blockers , cimetropium , eluxadoline , ipratropium ( oral inhalation), levosulpiride , loxapine , oxatomide , potassium chloride , potassium citrate , tiotropium , umeclidinium , avoid all the mentioned agents .

Indication

It indicated for the long-term once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

When not to Use

Hypersensitive to any of the ingredients .

Indibro Dpi Precautions

Precaution

The safety and efficacy of this medicine in patients with asthma have not been established. It is not indicated for the treatment of asthma .

Indibro Dpi Warnings

Warning 1

It should not be used more often or at higher doses than recommended or in conjunction with products containing other long-acting beta-adrenergic agonists or long-acting muscarinic antagonists, drug classes to which the components of this medicine belong . Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs .

Warning 2

Like other anticholinergic containing drugs, it should be used with caution in patients with narrow-angle glaucoma or urinary retention.

Warning 3

It should be used with caution in patients with urinary retention. Prescribers and patients should be alert for signs and symptoms of prostatic hyperplasia or bladder-neck obstruction (e.g., difficulty passing urine, painful urination). Instruct patients to consult a physician immediately should any of these signs or symptoms develop.