Kibon Iv Injection 1Mcg (1 Box = 10 Injections)

Name: Kibon Iv Injection 1Mcg (1 Box = 10 Injections)
Brand: RG PHARMA
Price: 2826.20

Brand : rg pharma

Rs. 2,826.20

Rs. 2,974.98

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Kibon Iv Specification

Requires Prescription (YES/NO)

Yes

Generics

Calcitriol

Used For

Osteoporosis

How it works

Calcitriol when administered by bolus injection is rapidly available in the blood stream. Vitamin D metabolites are known to be transported in blood, bound to specific plasma proteins. The pharmacologic activity of an administered dose of calcitriol is about 3 to 5 days. Two metabolic pathways for calcitriol have been identified, conversion to 1,24,25-(OH)3D3 and to calcitroic acid.

Kibon Iv Usage And Safety

Dosage

Calcitriol

Side Effects

The early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia include: Early Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, anorexia, abdominal pain and epigastric discomfort. Late Polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT and SGPT, ectopic calcification, hypertension, cardiac arrhythmias, nephrocalcinosis, sensory disturbance, dehydration, apathy, and, rarely, overt psychosis.

Drug Interactions

Concomitant use of magnesium-containing preparations should be used with caution or avoided since such use may lead to the development of hypermagnesemia. Corticosteroids with glucocorticoid activity may counteract the bone and mineral metabolism effects of vitamin D analogues.Cytochrome P450 enzyme-inducing anticonvulsants such as carbamazepine, phenobarbital and phenytoin mayreduce the effects of vitamin D because they increase vitamin D catabolism.

Indication

Calcitriol is indicated in the management of hypocalcemia in patients undergoing chronic renal dialysis. It has been shown to significantly reduce elevated parathyroid hormone levels. Reduction of PTH has been shown to result in an improvement in renal osteodystrophy.

When not to Use

Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Calcitriol is contraindicated in patients with previous hypersensitivity to calcitriol or any of its excipients

Kibon Iv Precautions

Precaution

Excessive dosage of calcitriol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium and phosphorus should be determined at least twice weekly. Should hypercalcemia develop, the drug should be discontinued immediately. It should be given cautiously to patients on digitalis, because hypercalcemia in such patients may precipitate cardiac arrhythmias.

Kibon Iv Warnings

Warning 1

Since calcitriol is the most potent metabolite of vitamin D available, prescription-based doses of vitamin D and its derivatives should be withheld or used with caution during treatment to avoid the risk of hypercalcemia.

Warning 2

A non-aluminum phosphate-binding compound should be used to control serum phosphorus levels in patients undergoing dialysis .

Warning 3

Overdosage of any form of vitamin D is dangerous . Progressive hypercalcemia due to overdosage of vitamin D and its metabolites may be so severe as to require emergency attention. Chronic hypercalcemia can lead to generalized vascular calcification, nephrocalcinosis and other soft-tissue calcification. The serum calcium times phosphate (Ca x P) product should not be allowed to exceed 70 mg2 /dL2 . Radiographic evaluation of suspect anatomical regions may be useful in the early detection of this condition.

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