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      masacol tablets 400mg (1 strip = 10 tablets) Product Image

      Masacol Tablets 400Mg (1 Strip = 10 Tablets)

      Rs. 406.80

      Rs. 428.20

      |

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      Masacol Tablets Specification

      Requires Prescription (YES/NO)

      Yes

      Generics

      Mesalazine

      Used For

      Acidity & Ulcers

      How it works

      Mesalazine has an anti-inflammatory effect through a mechanism that has not yet been fully clarified. Mesalazine inhibits migration of polymorph nuclear leukocytes and lipoxygenase of cells at concentrationsreached in the large intestine during treatment. The production of pro-inflammatory leukotrienes (LTB4 and 5-HETE) in macrophages of the intestinal wall is then inhibited. Mesalazine has been shown to activatePPAR-Y receptors which counteract nuclear activation of intestinal inflammatory responses.

      Masacol Tablets Usage And Safety

      Dosage

      Mesalazine

      Side Effects

      Common : Headache, diarrhea, abdominal pain, nausea, vomiting, rash, drug fever, dizziness, arthralgia and dyspepsiaRare : Myocarditis, pericarditis, anemia, tinnitus, paresthesia, flatulence, pruritus, urticaria, myalgia, interstitial nephritis, myocarditis, pancreatitis, abnormal renal , function, leucopenia, thrombocytopenia, agranulocytosis and neutropenia.

      Drug Interactions

      Digoxin , Azathioprine and 6-mercaptopurine , furosemide and spironolactone , warfarin , glucocorticoids , NSAIDs, methotrexate.

      Indication

      Mesalazine is indicated for the treatment of:- Mild to moderate acute exacerbations of ulcerative colitis.- Maintenance of remission of ulcerative colitis.- Maintenance of remission of crohn's ileo-colitis.

      When not to Use

      Mesalazine is contraindicated in:• Patients with a history of sensitivity to salicylates.• Patients with severe renal insufficiency.• Patients with severe hepatic insufficiency.• Children under 2 years of age.• Concomitant use of lactulose or similar preparations should be avoided.

      Masacol Tablets Precautions

      Precaution

      Patients on oral forms of mesalazine should have renal function monitored with serum creatinine levels measured prior to treatment start, every three months for the first year, then 6 monthly for the next 4 yearsand annually after that. Treatment with mesalazine should be discontinued if renal function deteriorates.

      Masacol Tablets Warnings

      Warning 1

      Following mesalazine treatment, serious blood dyscrasias have been reported rarely. If the patient develops unexplained bleeding, hematoma bruising, purpura, anemia, persistent fever or sore throat, hematological investigations should be performed. If there is suspicion of blood dyscrasia, treatment should be terminated.

      Warning 2

      In case of existing gastric or duodenal ulcers treatment should begin with caution based on theoretical grounds.

      Warning 3

      Caution should be used in patients with previous myopericarditis of allergic background regardless of its origin.

      Masacol Tablets Additional Information

      Pregnancy category

      Always consult your physician before using any medicine.

      Storage (YES/NO)

      Store this medicine at room temperature, away from direct light and heat.

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