Neo Pyrolate Iv Injection 1X10ml Ampoules

Brand : brookes pharma private limited

Rs. 1,791.40

Rs. 1,885.71

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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Glycopyrrolate USP , Neostigmine Methyl Sulphate BP

Used For

Anti-Muscaranic

How it works

Glycopyrrolate is an anti-cholinergic drug, which is a synthetic quaternary ammonium compound. It inhibits the muscarinic actions of acetylcholine; which results in reduction of gastrointestinal & urinary tract motility. It also inhibits salivary as well as bronchial secretions. Due to its highly polar quaternary ammonium group, it does not cross the blood brain barrier in contrast with atropine sulphate orscopolamine hydrobromide, which are non-polar tertiary amines and can cross blood brain barrier. Neostigmine belongs to “Reversible” Carbamate inhibitors group. These drugs inhibit or inactivate acetyl cholinesterase.They cause acetylcholine to accumulate at cholinergic receptors and as a result causes excessive stimulation of cholinergic receptors throughout the central and peripheral nervous system.

USAGE AND SAFETY

Dosage

Glycopyrrolate USP , Neostigmine Methyl Sulphate BP

Side Effects

The Glycopyrrolate component of Neo-Pyrolate Injection can give rise to dry mouth, difficulty in micturition, cardiac dysrhythmias, disturbances of visual accommodation and inhibition of sweating, headache, drowsiness, weakness, nausea and vomiting. The Neostigmine component of Neo-Pyrolate Injection can give rise to bradycardia, increased oropharyngeal secretions, cardiac dysrhythmias and increased gastrointestinal activity. If severe Neostigmine induced muscarinic side effects occur (bradycardia, increased oropharyngeal secretions, decreased cardiac conduction rate, bronchospasm or Increased Gastro-intestinal activity etc), these may be treated by the intravenous administration of Neo-Pyrolate Injection (Glycopyrrolate) 200-600 micrograms (0.2-0.6 mg).

Drug Interactions

Cyclopropane or halothane anaesthesia . Depolarising muscle relaxants .

Indication

Reversal of residual non-depolarising (competitive) neuromuscular block .

When not to Use

Neo-Pyrolate Injection should not be given to patients with known hypersensitivity to either of the two active ingredients. Neo-Pyrolate Injection should not be given to patients with mechanical obstruction of the gastrointestinal or urinary tracts. Neo-Pyrolate Injection should not be given in conjunction with suxamethonium as Neostigmine potentiates the depolarising myoneural blocking effects of this agent.

PRECAUTIONS

Precaution

Administer with caution to patients with bronchospasm, severe bradycardia or glaucoma. Administration of anticholinesterase agents to patients with intestinal anastomoses may produce rupture of the anastomosis or leakage of intestinal contents .

WARNINGS

Warning 1

Use with caution in patients with epilepsy or parkinsonism .

Warning 2

This product should be used cautiously in pyrexial patients due to inhibition of sweating.

Warning 3

Do not mix Neo-Pyrolate Injection with any other preparation.

ADDITIONAL INFORMATION

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.