Ogrel Tablets 75Mg - Buy Online at DVAGO®

How it works

Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Due to the irreversible binding, platelets exposed are affected for the remainder of their lifespan (approximately 7-10 days) and recovery of normal platelet function occurs at a rate consistent with platelet turnover. Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.

Description

OGREL TAB 75 MG 10'S

Generics

Clopidogrel

used for

Stroke

Requires Prescription (YES/NO)

Yes

Indication

Secondary prevention of atherothrombotic events : Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or establishedperipheral arterial disease. Prevention of atherothrombotic and thromboembolic events in atrial fibrillation: In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists (VKA) and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke.

Side Effects

Abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting, constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash, palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia and vertigo.

When not to Use

1.Hypersensitivity to the active substance. 2. Active pathological bleeding such as peptic ulcer or intracranial haemorrhage. 3.Severe hepatic impairment.

Dosage

Adults : 75mg daily with or without food. Non-ST segment elevation acute coronary syndrome : Adults - 300mg loading dose followed by 75mg daily given in combination with 75-100mg aspirin daily. Children : Not recommended. Always consult your doctor or pharmacist for dose adjustments.

Storage yes or /no

Store this medicine at room temperature, away from direct light and heat.

Precautions

Due to the risk of bleeding and haematological adverse reactions, blood cell count determination and/or other appropriate testing should be promptly considered whenever clinical symptoms suggestive of bleeding arise during the course of treatment. Patients should be followed carefully for any signs of bleeding including occult bleeding, especially during the first weeks of treatment and/or after invasive cardiac procedures or surgery.

Warning 1

Acquired haemophilia: in cases of confirmed isolated activated Partial Thromboplastin Time (aPTT) prolongation with or without bleeding, acquired haemophilia should be considered. Patients with a confirmed diagnosis, clopidogrel should be discontinued.

Warning 2

Recent ischaemic stroke: Clopidogrel cannot be recommended during the first 7 days after acute ischaemic stroke .

Warning 3

Hepatic impairment: Experience is limited in patients with moderate hepatic disease who may have bleeding diatheses. Clopidogrel should therefore be used with caution in this population .

Pregnancy category

Always consult your physician before using any medicine.

Drug Interactions

Warfarin , Glycoprotein IIb/IIIa inhibitors , Acetylsalicylic acid (ASA) , Heparin , Thrombolytics , NSAIDs , SSRIs , omeprazole and esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, carbamazepine, and efavirenz .

Ogrel 75Mg Tablets 10S (Pack Size 1 X 10S)

Brand : bosch pharmaceuticals

Per Box

Rs. 195.60

Rs. 205.88

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