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Prothiaden 25Mg Tablets 100S (Pack Size 10 X 10S)
Brand : abbot laboratories (pak) ltd
Per Box
Rs. 187.00
Rs. 197.00
How it works
Dosulepin is a tricyclic antidepressant that acts by increasing transmitter levels at central synapses, so producing a clinical antidepressant effect. In common with other tricyclics, Dosulepin inhibits the reuptake of noradrenaline and 5-hydroxytryptamine, with a significantly greater action on the reuptake of noradrenaline.
Description
PROTHIADEN TAB 25 MG 10X10'S
Generics
Dosulepin Hydrochloride
used for
Depression
Requires Prescription (YES/NO)
Yes
Indication
Dosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required.
Side Effects
Bone marrow depression, agranulocytosis , Hypersensitivity reactions , Inappropriate antidiuretic hormone (ADH) secretion, endocrine side effects , Hyponatremia , mania and paranoid delusions, suicidal ideation and suicidal behavior ,Tremors, drowsiness, convulsions, movement disorders, dizziness and headache , hypotension and cardiac arrhythmias , Dyspepsia, Abdominal pain, diarrhea and nausea , Skin rashes, sweating .
When not to Use
Dosulepin is contraindicated in patients with recent myocardial infarction, any degree of heart block or other cardiac arrhythmias. Dosulepin is contraindicated for the treatment of mania. Dosulepin is contraindicated for patients with severe liver disease. Dosulepin is contraindicated for patients with known hypersensitivity to Dosulepin hydrochloride or any the excipients.
Dosage
Adults : Initially, administer 75 mg daily in divided doses or as a single dose at night, increasing to 150 mg/day. In certain circumstances, e.g. in hospital use, dosages up to 225 mg/day have been used. Suggested regimen: 25 to 50 mg three times daily or 75 to 150 mg as a single dose at night. If 150 mg as a single dose is given at night, it is better to give a smaller dose for the first few nights. Elderly : The recommended dose is 50 to 75 mg daily. Elderly patients may require a lower starting dose and slow dose escalation. As with any tricyclic antidepressant, the initial dose should be increased with caution under close supervision . Children : The use of Dosulepin in children has not been studied . OR As directed by your physician .
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Precautions
Dosulepin is associated with high mortality in overdose. There is a low margin of safety between the (maximum) therapeutic dose and potentially fatal doses.
Warning 1
Depression is associated with an increased risk of suicidal thoughts, self harm and suicide (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs .
Warning 2
Avoid use in patients with a history of epilepsy, thyroid disease, mania or urinary retention and in those with narrow-angle glaucoma or symptoms suggestive of prostatic hypertrophy. Patients with hepatic impairment and those undergoing electroconvulsive therapy should also avoid dosulepin use .
Warning 3
Dosulepin may increase the risk of cardiovascular toxicity (cardiac arrhythmias, conduction disorders, cardiac failure and circulatory collapse), especially in the elderly.
Pregnancy category
Always consult your physician before using any medicine.
Drug Interactions
Selective serotonin reuptake inhibitors (SSRI) , alcohol and narcotic analgesics , sotalol, terfenadine, astemizole, halofantrine , bethanidine, debrisoquine, guanethidine , Barbiturates , methylphenidate.
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