Sildoso Capsules 8Mg (1 Box = 1 Strip)(1 Strip = 10 Capsules)

Brand : c.c.l (pvt) ltd .

Rs. 464.30

Rs. 488.70

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Sildoso Capsules Specification

Requires Prescription (YES/NO)

Yes

Generics

Silodosin

Used For

Benign Prostatic Hyperplasia

How it works

Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule and prostatic urethra. Blockade of these alpha-1 adrenoreceptors can cause smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in benign prostatic hyperplasia (BPH) symptoms.

Sildoso Capsules Usage And Safety

Dosage

Silodosin

Side Effects

Very Common : Ejaculatory disorders, including retrograde ejaculation and anejaculation. Common Dizziness, orthostatic hypotension, nasal congestion and diarrhoea. Uncommon Libido decreased, tachycardia, hypotension, nausea, dry mouth, abnormal liver function tests, skin rash, pruritus, urtricaria, drug eruption, erectile dysfunction and Intraoperative Floppy Iris Syndrome. Rare Syncope, loss of consciousness and palpitations.

Drug Interactions

CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil ) , Strong P-gp inhibitors such as cyclosporine , Antihypertensives , PDE-5 Inhibitors .

Indication

Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

When not to Use

Silodosin is contraindicated: • In patients with known hypersensitivity to silodosin or to any excipient of the product. • In patients with severe renal impairment. • In patients with severe hepatic impairment. • Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir). • Silodosin should not be administered to patients using concomitant alpha-blockers (e.g., prazosin, terazosin, doxazosin).

Sildoso Capsules Precautions

Precaution

As with all alpha-1 antagonists, a reduction in blood pressure can occur in individual cases during treatment with silodosin, as a result of which, rarely, syncope can occur. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit or lie down until the symptoms have disappeared.

Sildoso Capsules Warnings

Warning 1

Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently co-exist. Therefore, patients thought to have BPH should be examined prior to starting therapy with silodosin to rule out the presence of carcinoma of the prostate.

Warning 2

Intraoperative Floppy Iris Syndrome has been observed during cataract surgery in some patients on alpha-1 blockers or previously treated with alpha-1 blockers. Patients planning cataract surgery should be told to inform their ophthalmologist that they are taking silodosin .

Warning 3

Treatment with silodosin leads to a decrease in the amount of semen released during orgasm that may temporarily affect male fertility. This effect disappears after discontinuation of silodosin.