Sitaglu Tablets 100Mg 14'S - Buy Online at DVAGO®

How it works

Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclicAMP. GLP1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.

Description

SITAGLU TAB 100 MG 14'S

Generics

Sitagliptin

used for

Diabetes

Requires Prescription (YES/NO)

Yes

Indication

Sitagliptin is indicated in patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control as: - Monotherapy- Dual Therapy : In combination with metformin HCl or with a sulphonylurea or with a PPAR? agonist (i.e., thiazolidinediones) when the treatment with the single agent alone with diet and exercise does not provide adequate glycemic control.- Triple Therapy : In combination with metformin HCl and a sulphonylurea or with metformin HCl and a PPAR? (i.e., thiazolidinediones) when dual therapy with these agents, with diet and exercise, does not provide adequate glycemic control. - Combination with Insulin.

Side Effects

Upper respiratory-tract infections, headache and nasopharyngitis.

When not to Use

Sitagliptin is contraindicated in: - Patients with known hypersensitivity to sitagliptin or any of the components of the product. - Patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. - Children below 18 years of age.

Dosage

The recommended dose of Sitagliptin is 100mg once daily . Combination therapy , consider lower dose of sulfonylurea or insulin. Children : Not recommended. Renal Impairment : For patients with mild renal impairment (creatinine clearance [ClCr] = 50mL/min, approximately corresponding to serum creatinine levels of <1.7mg/dL in men and <1.5mg/dL in women), no dosage adjustment for sitagliptin is required.For patients with moderate renal impairment (ClCr =30 to <50 mL/min, approximately corresponding to serum creatinine levels of >1.7 to <3.0mg/dL in men and >1.5 to <2.5 mg/dL in women), the dose of sitagliptin is 50 mg once daily.For patients with severe renal impairment (ClCr <30 mL/min, approximately corresponding to serum creatinine levels of >3.0 mg/dL in men and >2.5 mg/dL in women) or with end-stage renal disease (ESRD) requiringhemodialysis or peritoneal dialysis, the dose of sitagliptin is 25mg once daily. Sitagliptin may be administered without regard to the timing of hemodialysis. Always consult with your doctor or pharmacist for dose adjustments.

Storage yes or /no

Store this medicine at room temperature, away from direct light and heat.

Precautions

After initiation of sitagliptin, patients should be observed carefully for signs and symptoms of pancreatitis. If pancreatitis is suspected, sitagliptin should promptly be discontinued and appropriate management should be initiated.

Warning 1

When sitagliptin is used in combination with a sulphonylurea or with insulin, medications known to cause hypoglycemia the incidence of hypoglycemia increases when used in combination with a sulphonylurea or with insulin. Therefore, a lower dose of sulphonylurea or insulin may be required to reduce the risk of hypoglycemia.

Warning 2

An association between dipeptidyl peptidase-4 (DPP-4) inhibitor treatment and heart failure has been observed in trials for two other members of the DPP-4 inhibitor class. Consider the risks and benefits of Sitagliptin prior to initiating treatment in patients at risk for heart failure, such as those with a prior history of heart failure and a history of renal impairment, and observe these patients for signs and symptoms of heart failure during therapy. Advise patients of the characteristic symptoms of heart failure and to immediately report such symptoms. If heart failure develops, evaluate and manage according to current standards of care and consider discontinuation.

Warning 3

If a hypersensitivity reaction is suspected, discontinue this medicine, assess for other potential causes for the event, and institute alternative treatment for diabetes. Angioedema has also been reported with other DPP-4 inhibitors. Use caution in a patient with a history of angioedema with another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with sitagliptin.

Pregnancy category

Always consult your physician before using any medicine.

Drug Interactions

Digoxin : Sitagliptin has a small effect on plasma digoxin concentrations. No dosage adjustment of digoxin is recommended. However, patients at risk of digoxin toxicity should be monitored for this when sitagliptin and digoxin are administered concomitantly.

Sitaglu 100Mg Tablets 14S (Pack Size 2 X 7S)

Brand : hilton pharma

Per Strip

Rs. 331.52

Rs. 349.00

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