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How it works

There is evidence that malfunctioning of glutamatergic neurotransmission, in particular at N-methyl-D-aspartate (NMDA)-receptors, contributes to both expression of symptoms and disease progression in neurodegenerative dementia. Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA-receptor antagonist. It blocks the effects of pathologically elevated tonic levels of glutamate that may lead to neuronal dysfunction .

Description

STIR-UP TAB 10 MG 20'S

Generics

Memantine Hydrochloride

used for

Alzheimer

Requires Prescription (YES/NO)

Yes

Indication

Treatment of patients with moderately severe to severe Alzheimer’s disease .

Side Effects

Common: Headache, sleepiness, constipation, elevated liver function test, dizziness, balance disorders, shortness of breath, high blood pressure and drug hypersensitivity ; Uncommon: Tiredness, fungal infections, confusion, hallucinations, vomiting, abnormal gait, heart failure and venous blood clotting (thrombosis/thromboembolism).

When not to Use

Hypersensitivity to memantine hydrochloride or to any of the excipients . Children and adolescents below the age of 18 years, as safety and efficacy have not been established.

Dosage

Adults: The maximum daily dose is 20 mg per day. In order to reduce the risk of side-effects the maintenance dose is achieved by upward titration of 5 mg per week over the first 3 weeks as follows: Treatment should be started with 5 mg daily (in the morning) during the 1st week. In the 2nd week 10 mg per day and in the 3rd week 15 mg per day is recommended. From the 4th week on, treatment can be continued with the recommended maintenance dose of 20 mg per day. Elderly: The recommended dose for patients over the age of 65 years is 20 mg per day. OR As directed by your physician.

Storage yes or /no

Store this medicine at room temperature, away from direct light and heat.

Precautions

Based on pharmacological considerations and single case reports, caution is recommended with patients suffering from epilepsy.

Warning 1

Concomitant use of N-methyl-D-aspartate (NMDA)-antagonists such as amantadine, ketamine or dextromethorphan should be avoided. These medicines act at the same receptor system as this product and therefore adverse drug reactions (mainly CNS-related) may be more frequent or more pronounced .

Warning 2

In most clinical trials with Memantine, patients with recent myocardial infarction, congestive heart failure (NYHA III-IV) and uncontrolled hypertension were excluded. As a consequence only limited data are available and patients with these conditions should be closely supervised.

Warning 3

Moderately severe to severe Alzheimer’s disease usually causes impairment of driving performance and compromises the ability to use machinery. Furthermore, Memantine may change reactivity such that outpatients should be warned to take special care when driving a vehicle or operating machinery.

Pregnancy category

Always consult your physician before using any medicine.

Drug Interactions

L-dopa, dopaminergic agonists, and anticholinergics , antispasmodic medicines, dantrolene or baclofen , amantadine , cimetidine, ranitidine, procainamide, quinidine, quinine and nicotine , hydrochlorothiazide (HCT) , dextromorphan , oral anticoagulants .

Stir-Up 10Mg Tablets 20S (Pack Size 2 X 10S)

Brand : nabiqasim industries

Per Strip

Rs. 388.00

Rs. 408.40

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