Tenofo-B 300Mg Tablets 30S

How it works

Tenofovir disoproxil is absorbed and converted to the active substance tenofovir, which is a nucleoside monophosphate (nucleotide) analogue. Tenofovir is then converted to the active metabolite, tenofovir diphosphate, an obligate chain terminator, by constitutively expressed cellular enzymes .Tenofovir diphosphate inhibits HIV1 reverse transcriptase and the HBV polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into DNA, by DNA chain termination.

Description

TENOFO-B TAB 300 MG 30'S

Generics

Tenofovir disoproxil fumarate

used for

Hepatitis

Requires Prescription (YES/NO)

Yes

Indication

It (Tenofovir disoproxil fumarate) is indicated: - In combination with at least two other antiretroviral agents for the management of HIV infected adults. - For the treatment of chronic hepatitis B in adults withcompensated liver disease, with evidence of active viral replication, persistant elevated serum alanine aminotransferase (ALT) level and histological evidence of active inflammation and fibrosis.

Side Effects

Diarrhea, nausea and anorexia , peripheral neuropathy, headache, dizziness, insomnia, depression, asthenia, sweating and myalgia , liver enzymes, hypertriglyceridemia, hyperglycemia and neutropenia , Lactic acidosis.

When not to Use

Tenofovir disoproxil fumarate is contraindicated in patients with known hypersensitivity to tenofovir or to any of the components of the formulation. It should not be administered concurrently with other tenofovir containing combinations formulation or with adefovir dipivoxil. Tenofovir disoproxil fumarate is not recommended for use in children below the age of 18 years.

Dosage

Adults: The recommended dose for the treatment of HIV or for the treatment of chronic hepatitis B is 300mg (one tablet) once daily taken orally with food or as per physician directed.

Storage yes or /no

Store this medicine at room temperature, away from direct light and heat.

Precautions

Patients receiving tenofovir disoproxil fumarate or any other antiretroviral therapy may continue to develop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with HIV associated diseases.

Warning 1

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Warning 2

Tenofovir disoproxil fumarate may be associated with reduction in bone density and patients should be observed for evidence of bone abnormalities.

Warning 3

It is recommended that creatinine clearance is calculated in all patients prior to initiating therapy and as clinically appropriate, during tenofovir disoproxil fumarate therapy.

Pregnancy category

Always consult your physician before using any medicine.

Drug Interactions

Didanosine , Atazanavir , amivudine and abacavir , tracrolimus.

Brand : getz pharma pakistan

Per Box

Rs. 3277.50

Rs. 3450.00

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