Trioptal 600Mg Tablets 50S (Pack Size 5 X 10S)
Brand : novartis pharmaceuticals
How it works
The pharmacological activity of oxcarbazepine is primarily exerted through the metabolite (MHD) . The mechanism of action of oxcarbazepine and MHD is thought to be mainly based on the blockade of voltage-sensitive sodium channels, thus resulting in stabilisation of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminishment of propagation of synaptic impulses. In addition, increased potassium conductance and modulation of high-voltage activated calcium channels may also contribute to the anticonvulsant effects. No significant interactions with brain neurotransmitter or modulator receptor sites were found.
TRIOPTAL TAB 600 MG 50'S
Requires Prescription (YES/NO)
It is used to treat partial seizures with or without secondarily generalised tonic-clonic seizures.
Very common (may affect more than 1 in 10 people): • tiredness; headache; dizziness; drowsiness; feeling sick (nausea); being sick (vomiting); double vision. Common (may affect up to 1 in 10 people): • weakness; memory disturbances; impaired concentration; apathy; agitation; confusion; blurred vision; visual disturbance; constipation; diarrhoea; stomach (abdominal) pain; acne; hair loss, balance disturbances; weight increased; speech disorder. Uncommon (may affect up to 1 in 100 people): • High blood pressure; hives. • You may also have raised levels of liver enzymes while taking oxcarbazepine.
When not to Use
Do not take If you are allergic to oxcarbazepine or any of the other ingredients of this medicine or if you are allergic to eslicarbazepine.
Monotherapy : Adults : Initial : 300mg twice daily. Titrate : Increase by 300mg/day every 3 day. Maintenance : 1200mg/day. Children : 4-16yr : Initial : 4-5mg/kg twice daily. Titrate : Increase by 5mg/kg/day every 3 day. Maintenance (mg/day) : 20kg : Initial 600mg, Max : 900mg. 25-30kg : Initial : 900mg. Max : 1200mg. Max : 1500mg. 50-55kg : Initial : 2100mg. 70kg: Initial : 1500mg Max : 2100mg. Adjunct Therapy : Adults : Initial : 300mg twice daily. Titrate : Increase weekly by max of 600mg/day . Maintenance : 600mg twice daily. Children : 4-16yr : Initial : 4-5mg/kg twice daily . Max : 600mg twice daily. Titrate : Increase over 2 wk. Maintenance (mg/kg) : 20-29kg : 900mg. 29.1-39kg : 1200mg. >39kg : 1800mg. OR As directed by your physician.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Hypothyroidism is an adverse reaction (with “uncommon” frequency, of oxcarbazepine. Considering the importance of thyroid hormones in children's development after birth, thyroid function monitoring is recommended in the pediatric age group while on oxcarbazepine therapy.
Class I (immediate) hypersensitivity reactions including rash, pruritus, urticaria, angioedema and reports of anaphylaxis have been received in the post-marketing period. Cases of anaphylaxis and angioedema involving the larynx, glottis, lips and eyelids have been reported in patients after taking the first or subsequent doses of Oxcarbazepine. If a patient develops these reactions after treatment , the drug should be discontinued and an alternative treatment started.
Very rare cases of hepatitis have been reported, which in most cases resolved favourably. When a hepatic event is suspected, liver function should be evaluated and discontinuation of oxcarbazepine should be considered. Caution should be exercised when treating patients with severe hepatic impairment.
Discontinuation of the medicinal product should be considered if any evidence of significant bone marrow depression develops.
Always consult your physician before using any medicine.
Hormonal contraceptives, such as the pill , Other antiepileptic and enzyme inducing medicines, such as carbamazepine, phenobarbital, phenytoin or lamotrigine and rifampicin , diuretics , desmopressin , indometacin , Lithium and monoamine oxidase inhibitors , ciclosporin and tacrolimus.
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