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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Losartan Potassium

Used For

Hypertension

How it works

Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland).

USAGE AND SAFETY

Dosage

Losartan Potassium

Side Effects

Symptoms of an allergic reaction are swelling of the face, lips, throat or tongue , Low blood pressure may cause you to feel faint or dizzy , diarrhea , tiredness , low blood sugar , chest pain , high blood potassium , low blood pressure .

Drug Interactions

Hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital , Rifampin , Ketoconazole , Fluconazole , potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium , Lithium , NSAIDs , aliskiren .

Indication

It is used: • Alone or with other blood pressure medicines to lower high blood pressure (hypertension).• To lower the chance of stroke in patients with high blood pressure and a heart problem called left ventricular hypertrophy. It may not help Black patients with this problem.• To slow the worsening of diabetic kidney disease (nephropathy) in patients with type 2 diabetes who have or had high blood pressure.

When not to Use

Do not take losartan potassium if you are allergic to any of the ingredients in in the list.

PRECAUTIONS

Precaution

Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patients, a lower dose should be considered for patients with impaired liver function .

WARNINGS

Warning 1

As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function have been reported in susceptible individuals treated with losartan potassium; in some patients, these changes in renal function were reversible upon discontinuation of therapy.

Warning 2

Electrolyte imbalances are common in patients with renal impairment, with or without diabetes, and should be addressed.

Warning 3

A patient receiving losartan potassium should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.