Filgen Injection Specification
Requires Prescription (YES/NO)
Yes
Generics
Filgrastim
Used For
Blood Cell Deficiecy
How it works
It is a glycoprotein which regulates the production and release of functional neutrophils from the bone marrow. Recombinant methionyl human granulocyte-colony stimulating factor (r-Met-HU-G-CSF) i.e. filgrastimcauses marked increases in peripheral blood neutrophil counts within twenty four hours, with minor increases in monocytes. In some SCN (severe chronic neutropenia) patients filgrastim can also induce a minor increase in the number of circulating eosinophils and basophils relative to baseline; some of these patients may present with eosinophilia or basophilia already prior to treatment. Elevations of neutrophil counts are dose-dependent at recommended doses. Neutrophils produced in response to filgrastim show normal or enhanced function as demonstrated by tests of chemotactic and phagocytic function. Following termination of filgrastim therapy, circulating neutrophil counts decrease by 50% within 1 to 2 days, and to normal levels within 1 to 7 days.
Filgen Injection Usage And Safety
Dosage
Filgrastim
Side Effects
Very common side effects (may affect more than 1 in 10 people): Decrease of platelets which reduces the ability of blood to clot (thrombocytopenia) , low red blood cell count (anaemia) , headache , diarrhoea , vomiting , nausea , unusual hair loss or thinning (alopecia) , tiredness (fatigue) , soreness and swelling of the digestive tract lining which runs from the mouth to the anus (mucosal inflammation) , fever (pyrexia) . Common side effects (may affect up to 1 in 10 people): Inflammation of the lung (bronchitis) , upper respiratory tract infection , urinary tract infection , decreased appetite , trouble sleeping (insomnia) , dizziness , decreased feeling of sensitivity, especially in the skin (hypoaesthesia) , tingling or numbness of the hands or feet (paraesthesia) , low blood pressure (hypotension) , high blood pressure (hypertension) , cough , coughing up blood (haemoptysis) .
Drug Interactions
Fluorouracil
Indication
It can be used: To increase the number of white blood cells after treatment with chemotherapy to help prevent infections; to increase the number of white blood cells after a bone marrow transplant to help prevent infections; before high-dose chemotherapy to make the bone marrow produce more stem cells which can be collected and given back to you after your treatment. These can be taken from you or from a donor. The stem cells will then go back into the bone marrow and produce blood cells.
When not to Use
Do not use if you are allergic to filgrastim or any of the other ingredients of this medicine.
Filgen Injection Precautions
Precaution
Hypersensitivity, including anaphylactic reactions, occurring on initial or subsequent treatment have been reported in patients treated with filgrastim. Permanently discontinue filgrastim in patients with clinically significant hypersensitivity. Do not administer filgrastim to patients with a history of hypersensitivity to filgrastim or pegfilgrastim.
Filgen Injection Warnings
Warning 1
Filgrastim should not be administered to patients with severe congenital neutropenia who develop leukaemia or have evidence of leukaemic evolution .
Warning 2
As with all therapeutic proteins, there is a potential for immunogenicity. Rates of generation of antibodies against filgrastim is generally low. Binding antibodies do occur as expected with all biologics; however, they have not been associated with neutralising activity at present .
Warning 3
Glomerulonephritis has been reported in patients receiving filgrastim and pegfilgrastim. Generally, events of glomerulonephritis resolved after dose reduction or withdrawal of filgrastim and pegfilgrastim. Urinalysis monitoring is recommended.
Filgen Injection Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store in a refrigerator (2°C–8°C). Do not Freeze .
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