Abriva 400Mg Tablets 28S

Name: Abriva 400Mg Tablets 28S
Brand: C.C.L (PVT) LTD .
Price: 3325

Brand : c.c.l (pvt) ltd .

Rs. 3,325.00

Rs. 3,500.00

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Abriva 400Mg Specification

Requires Prescription (YES/NO)

Yes

Generics

Sofosbuvir

Used For

Hepatitis

How it works

Sofosbuvir is a direct-acting antiviral agent against the hepatitis C virus. It is a pan-genotypic inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.

Abriva 400Mg Usage And Safety

Dosage

Sofosbuvir

Side Effects

Very Common : Hemoglobin decreased, insomnia, headache, nausea, blood bilirubin increased, fatigue and irritability.Common: Nasopharyngitis, anemia, depression, disturbance in attention, dyspnea, dyspnea exertional, cough, abdominal discomfort, constipation, dyspepsia, alopecia, dry skin, pruritus, arthralgia, back pain, muscle spasms, myalgia pyrexia and asthenia.

Drug Interactions

P-gp inducers (e.g., rifampin or St. John's wort) , Antiarrhythmics , Anticonvulsants , carbamazepine, phenytoin, phenobarbital or oxcarbazepine , Antimycobacterials e.g rifabutin or rifapentine , HIV Protease Inhibitors e.g tipranavir/ritonavir , Analeptics.

Indication

Sofosbuvir is indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen in adults.

When not to Use

- Sofosbuvir is contraindicated in patients with known hypersensitivity to Sofosbuvir or to any excipient of the product.- When Sofosbuvir is used in combination with ribavirin or peginterferon alfa/ribavirin, the contraindications applicable to those agents are applicable to combination therapies.

Abriva 400Mg Precautions

Precaution

Sofosbuvir is not recommended for administration as monotherapy and should be prescribed in combination with other medicinal products for the treatment of hepatitis C infection.

Abriva 400Mg Warnings

Warning 1

Sofosbuvir should only be co-administered with other direct-acting antiviral medicinal products if the benefit is considered to outweigh the risks based upon available data.

Warning 2

Sofosbuvir has moderate influence on the ability to drive and use machine. Patients should be cautioned about the risk of an influence on their ability to drive a car and operate machinery.

Warning 3

When sofosbuvir is used in combination with ribavirin or peginterferon alfa/ribavirin, extreme caution must be taken to avoid pregnancy in female patients and female partners of male patients. Patients must have a negative pregnancy test prior to initiating therapy, use at least 2 effective methods of contraception and have monthly pregnancy tests.

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