Anthracin 50Mg Inj 1S

Name: Anthracin 50Mg Inj 1S
Brand: ATCO LABORATORIES LIMITED
Price: 2938.78

Brand : atco laboratories limited

Rs. 2,938.78

Rs. 3,093.45

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Anthracin 50Mg Specification

Requires Prescription (YES/NO)

Yes

Generics

Epirubicin Hydrochloride

Used For

Cancer

How it works

The mechanism of action of Epirubicin Hydrochloride is related to its ability to bind to DNA. Cell culture studies have shown rapid cell penetration, localisation in the nucleus and inhibition of nucleic acid synthesis and mitosis. Pharmorubicin has proved to be active on a wide spectrum of experimental tumours including L1210 and P388 leukaemias, sarcomas SA180 (solid and ascitic forms), B16 melanoma, mammary carcinoma, Lewis lung carcinoma and colon carcinoma . It has also shown activity against human tumours transplanted into athymic nude mice (melanoma, mammary lung, prostatic and ovarian carcinomas).

Anthracin 50Mg Usage And Safety

Dosage

Epirubicin Hydrochloride

Side Effects

Decrease in the production of blood cells (bone marrow depression; resulting in a shortage of white blood cells, red blood cells, platelets), which involves an increased sensitivity to infections and anaemia. - Hair loss (alopecia, in 60-90% of treated cases. It involves poor beard growth in men. Hair loss is dose-dependent and in most cases reversible) - Red coloration of urine for 1 to 2 days after administration , Infection , Hot flashes , loss of appetite (anorexia), dehydration , Mucous membrane inflammation (mucositis; can occur 5 to 10 days after the start of the treatment), inflammation of the mucous membrane of the oesophagus (esophagitis) or mouth (stomatitis), vomiting, diarrhea which can result in dehydration, nausea (nausea and vomiting often occur within the first 24 hours (in nearly all patients)) - Redness at infusion site .

Drug Interactions

Cimetidine , Paclitaxel and docetaxel , Calcium channel blockers , Interferon alfa-2b , Quinine , Antibiotics such as sulphonamide and chloramphenicol. - Antiretroviral , Diphenylhydantoin , Painkillers such as amidopyrin derivatives , Dexrazoxane , Dexverapamil .

Indication

Epirubicin is administered for the treatment of: - Breast cancer; - Stomach cancer; - Epirubicin hydrochloride is also used intravesically (directly into the bladder) to treat early (superficial) urinary bladder cancer and to help prevent recurrence of bladder cancer after surgery.

When not to Use

Hypersensitivity to the active substance or to any of the excipients .

Anthracin 50Mg Precautions

Precaution

Epirubicin hydrochloride should be administered only under the supervision of qualified physicians experienced in the use of cytotoxic therapy.

Anthracin 50Mg Warnings

Warning 1

The patient should be monitored closely during the subsequent period of time, as necrosis may occur after several weeks extravasation occurs, a plastic surgeon should be consulted with a view to possible excision.

Warning 2

Epirubicin may induce hyperuricemia because of the extensive purine catabolism that accompanies rapid drug-induced lysis of neoplastic cells (tumor-lysis syndrome). Blood uric acid levels, potassium, calcium phosphate, and creatinine should be evaluated after initial treatment. Hydration, urine alkalinization, and prophylaxis with allopurinol to prevent hyperuricemia may minimize potential complications of tumor-lysis syndrome.

Warning 3

Vaccination with a live vaccine should be avoided in patients receiving epirubicin hydrochloride. Killed or inactivated vaccines may be administered; however, the response to such vaccines may be diminished.

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