Clavir 60Mg Tablets 28S

Name: Clavir 60Mg Tablets 28S
Brand: HILTON PHARMA
Price: 1197

Brand : hilton pharma

Rs. 1,197.00

Rs. 1,260.00

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Clavir 60Mg Specification

Requires Prescription (YES/NO)

Yes

Generics

Daclatasvir

Used For

Hepatitis

How it works

Daclatasvir is a direct acting antiviral agent (DAA) against the hepatitis C virus. Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex. Daclatasvir inhibits both viral RNA replication and virion assembly. Daclatasvir interacts with the N-terminus within Domain 1 of the protein, which may cause structural distortions that interfere with NS5A functions.

Clavir 60Mg Usage And Safety

Dosage

Daclatasvir

Side Effects

Very Common : Anemia, headache, nausea and fatigue.Common : Decreased appetite, depression, anxiety, insomnia, dizziness, migraine, hot flush, cough, dyspnea, dyspnea exertional, nasal congestion, diarrhea, abdominal pain upper, constipation, flatulence, gastroesophageal reflux disease, dry mouth, vomiting, pruritus, dry skin, alopecia, rash, arthralgia, myalgia and irritability .

Drug Interactions

Protease inhibitors: Atazanavir with ritonavir, Atazanavir with cobicistat Indinavir, Nelfinavir, Saquinavir, Telaprevir, Boceprevir ; Other antiretrovirals: Cobicistat-containing antiretroviral regimens Examples: atazanavir/cobicistat, elvitegravir/cobicistat/emtric itabine/ tenofovir disoproxil fumarate ; Non-nucleoside reverse transcriptase inhibitors (NNRTI): Efavirenz, Etravirine, Nevirapine ; Strong CYP3A inhibitors : Examples: clarithromycin, itraconazole, ketoconazole, nefazodone, posaconazole, telithromycin, voriconazole ; Moderate CYP3A inducers : Examples: bosentan, dexamethasone, modafinil, nafcillin, rifapentine

Indication

It is indicated in combination with sofosbuvir, with or without ribavirin for the treatment of chronic hepatitis C virus (HCV) infections in adults.

When not to Use

Daclatasvir is contraindicated: In patients with hypersensitivity to Daclatasvir or to any excipients of the product.- In combination drugs that strongly induce cytochrome P450 3A4 and thus may lead to lower exposure and loss of efficacy of Daclatasvir. - The combination of Daclatasvir with peginterferon alfa and ribavirin is contraindicated in women who are pregnant or may become pregnant and men whose female partners are pregnant because of the risks of birth defects and fetal death associated with ribavirin.- Since Daclatasvir is used in combination with other medicinal products, the contraindications applicable to those medicinal products are applicable to the combination regimen.

Clavir 60Mg Precautions

Precaution

The concomitant use of Daclatasvir and other drugs may result in known or potentially significant drug interactions, some may lead to: - Therapeutic effect loss of Daclatasvir and development of resistance. - Dose adjustment of concomitant drugs or Daclatasvir. - Clinically significant adverse reactions possibly from greater exposures of concomitant drugs or Daclatasvir.

Clavir 60Mg Warnings

Warning 1

A moderate treatment regimen of Daclatasvir and sofosbuvir or ribavirin for 24 weeks is proposed for patients with Child-Pugh C. Ribavirin may be added based on clinical assessment of an individual patient.

Warning 2

It is recommended that patients are closely monitored when initiating Daclatasvir in combination with sofosbuvir. Patients who are identified as being at high risk of bradyarrhythmia should be continuously monitored for 48 hours in an appropriate clinical setting .

Warning 3

All patients receiving Daclatasvir and sofosbuvir in combination with amiodarone with or without other drugs that lower heart rate should also be warned of the symptoms of bradycardia and heart block.

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