Depo-Medrol 40Mg/Ml 1 Ml Injection
Brand : pfizer laboratories
How it works
It is a sterile aqueous suspension of the synthetic glucocorticoid methylprednisolone acetate. It has a strong and prolonged anti-inflammatory, immunosuppressive and anti-allergic activity. It can be administered I.M. for a prolonged systemic activity as well as In Situ for a local treatment. The prolonged activity of this medicine is explained by the slow release of the active substance .
DEPO-MEDROL INJ 40 MG 1 ML
Requires Prescription (YES/NO)
Corticosteroid responsive conditions such as hay fever , asthma , rheumatoid arthritis , osteoarthritis , collagen disease , dermatoses.
Allergic reactions: Angioedema. Blood and lymphatic system disorders: Leukocytosis Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, cardiac failure congestive (in susceptible patients), fat embolism, hypertension, hypotension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary oedema, syncope, tachycardia, thromboembolism, thrombophlebitis, thrombosis, vasculitis. Dermatologic: Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, oedema peripheral, erythema, skin hyperpigmentation, skin hypopigmentation, impaired healing, rash, abscess sterile, skin striae, suppressed reactions to skin tests, skin atrophy, thinning scalp hair, urticaria, angioedema, pruritus, hyperhidrosis, injection site reaction and injection site infection. Kaposi’s sarcoma has been reported to occur in patients receiving corticosteroid therapy .
When not to Use
It is contraindicated: In patients with known hypersensitivity to any components of the product , In patients with systemic fungal infections , In idiopathic thrombocytopenic purpura when administered intramuscularly .
Adults : Only sodium succinate may be given IV ; methylprednisolone sodium succinate is highly soluble and has a rapid effect by IM and IV routes . Anti-inflammatory or immunosuppresive : IM : 10-80mg every 1-2 wk. Arthritis : Intra-articular : Administer every 1-5 wk . Large joints (e.g. knee , ankle ) : 20-80mg ; Medium joints (e.g elbow , wrist ) : 10-40mg ; small joints ; 4-10mg. Dermatitis : Acute severe : IM : 80-120 mg as a single dose . Chronic : IM : 40-120 mg every 5-10 days . OR As directed by your physician.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
It should not be administered by any route other than those listed. It is critical that, during administration of this medicine , appropriate technique be used and care taken to assure proper route of administration.
Kaposi’s sarcoma has been reported to occur in patients receiving corticosteroid therapy. Discontinuation of corticosteroids may result in clinical remission.
Appropriate examination of any joint fluid present is necessary to exclude a septic process. A marked increase in pain accompanied by local swelling, further restriction of joint motion, fever and malaise are suggestive of septic arthritis. If this complication occurs and the diagnosis of sepsis is confirmed, appropriate antimicrobial therapy should be instituted.
Thrombosis including venous thromboembolism has been reported to occur with corticosteroids. As a result corticosteroids should be used with caution in patients who have or may be predisposed to thromboembolic disorders.
Always consult your physician before using any medicine.
Live vaccines or other vaccines , anticoagulants , hypoglycaemic agents , antihypertensives , diuretics , erythromycin , rifamycin , amphotericin , azole antifungals , ritonavir , cyclosporin , cardiac glycosides . Oestrogens including oral contraceptives , somatropin. Carbamazepine , phenytoin , primidone , barbitturates . Muscle relaxants , NSAIDs , salicylates , sympathomimetics , mifepristone , methotrexate , theophylline , asprepitant .
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