Diovan 320Mg Tablets 28S (Pack Size 4 X 7S)

Brand : novartis pharmaceuticals

Rs. 3,405.92

Rs. 3,585.12

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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Valsartan

Used For

Hypertension

How it works

Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

USAGE AND SAFETY

Dosage

Valsartan

Side Effects

Common : Viral infections, neutropenia, hyperkalemia, dizziness, postural dizziness, vertigo, hypotension, orthostatic hypotension, renal failure and impairment.Uncommon : Upper respiratory tract infection, pharyngitis, sinusitis, insomnia, decreased libido, syncope, vertigo, cardiac failure, hypotension, cough, diarrhea, abdominal pain, back pain, fatigue, asthenia, headache and oedema. Rare : Dizziness.

Drug Interactions

Lithium , Non-steroidal anti-inflammatory medicines (NSAIDs), including selective COX-2 inhibitors, acetylsalicylic acid >3 g/day), and non-selective NSAIDs , inhibitors of the uptake transporter (eg. rifampin, ciclosporin) or efflux transporter (eg. ritonavir) .

Indication

Valsartan is indicated for the treatment of the following conditions: • Hypertension. • Heart failure (NYHA class II-IV) in patients receiving usual therapy (e.g. diuretics, digitalis) who are intolerant to ACE inhibitors. • To improve survival following myocardial infarction in clinically stable patients with clinical or radiological evidence of left ventricular failure and/or with left ventricular systolic dysfunction .

When not to Use

Valsartan is contraindicated in patients with:- Patients with known hypersensitivity to valsartan or to any excipient of the product.- Patients with severe hepatic impairment, biliary cirrhosis and cholestasis.- Second and third trimester of pregnancy.- The concomitant use of valsartan with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m2).

PRECAUTIONS

Precaution

Patients with primary hyperaldosteronism should not be treated with valsartan as their renin-angiotensin system is not activated.

WARNINGS

Warning 1

Concomitant use with potassium supplements, potassium-sparing diuretics, salt substitutes containing potassium, or other agents that may increase potassium levels (heparin, etc.) is not recommended. Monitoring of potassium should be undertaken as appropriate.

Warning 2

In patients with bilateral renal artery stenosis or stenosis to a solitary kidney, the safe use of valsartan has not been established. However, other agents that affect the renin-angiotensin system may increase blood urea and serum creatinine in patients with unilateral renal artery stenosis, therefore monitoring of renal function is recommended when patients are treated with valsartan.

Warning 3

In patients with mild to moderate hepatic impairment without cholestasis, valsartan should be used with caution.