Duricef 90Ml Syrup 250Mg/5Ml

Brand : glaxosmithkline pakistan

Rs. 777.67

Rs. 818.60

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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Cefadroxil

Used For

Bacterial Infection

How it works

Cefadroxil is a first-generation cephalosporin antibiotic. It is bactericidal, and acts by inhibiting synthesis of the bacterial cell wall. Bacterial cell wall is held rigid and protected against osmotic rupture by peptidoglycan. Cefadroxil inhibits the final cross linking stage of peptidoglycan production by binding to and inactivating transpeptidase, which is a penicillin binding protein on the inner surface of the bacterial cell membrane may result in overgrowth of non-susceptible organisms. Careful observation of the patients is essential. If super infection occurs during the therapy, appropriate measures should be taken.

USAGE AND SAFETY

Dosage

Cefadroxil

Side Effects

It is generally well-tolerated. The common side effects are gastrointestinal disturbances (diarrhoea), hypersensitivity reactions (skin rashes). Other side effects are nausea and vomiting. Other reactions reported rarely are genital pruritus, genital moniliasis, vaginitis. Sometimes it causes anaphylaxis, erythema multiforme, toxic epidermal necrolysis, fever, abdominal pain, super infection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage. Several cephalosporins have been implicated triggering seizures, particularly in patients with renal impairment .

Drug Interactions

Loop diuretics , anticoagulants , other antibiotics , antiplatelets , colestyramine.

Indication

Cefadroxil is indicated in the treatment of mild to moderate infections of the respiratory tract (Pharyngitis & tonsillitis), urinary tract, skin and skin structures and bone caused by susceptible organisms and as an alternative to penicillin in patients with a history of hypersensitivity reactions.

When not to Use

Contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

PRECAUTIONS

Precaution

In patients with known or suspected renal impairment, careful clinical observation and appropriate laboratory studies should be made prior to and during the therapy.

WARNINGS

Warning 1

Before starting therapy, check the hypersensitivity reaction to cefadroxil, cephalosporins and penicillins. If an allergic reaction occurs, discontinue the drug .

Warning 2

Prolonged use of Cefadroxil may result in overgrowth of non-susceptible organisms.

Warning 3

Careful observation of the patients is essential if super infection occurs during the therapy, appropriate measures should be taken.