Duricef 250Mg/5Ml Syrup 90Ml
Brand : glaxo smith kline pakistan
How it works
Cefadroxil is a first-generation cephalosporin antibiotic. It is bactericidal, and acts by inhibiting synthesis of the bacterial cell wall. Bacterial cell wall is held rigid and protected against osmotic rupture by peptidoglycan. Cefadroxil inhibits the final cross linking stage of peptidoglycan production by binding to and inactivating transpeptidase, which is a penicillin binding protein on the inner surface of the bacterial cell membrane may result in overgrowth of non-susceptible organisms. Careful observation of the patients is essential. If super infection occurs during the therapy, appropriate measures should be taken.
DURICEF 250MG/5ML SYP 90ML
Requires Prescription (YES/NO)
Cefadroxil is indicated in the treatment of mild to moderate infections of the respiratory tract (Pharyngitis & tonsillitis), urinary tract, skin and skin structures and bone caused by susceptible organisms and as an alternative to penicillin in patients with a history of hypersensitivity reactions.
It is generally well-tolerated. The common side effects are gastrointestinal disturbances (diarrhoea), hypersensitivity reactions (skin rashes). Other side effects are nausea and vomiting. Other reactions reported rarely are genital pruritus, genital moniliasis, vaginitis. Sometimes it causes anaphylaxis, erythema multiforme, toxic epidermal necrolysis, fever, abdominal pain, super infection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage. Several cephalosporins have been implicated triggering seizures, particularly in patients with renal impairment .
When not to Use
Contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Children : Under 1yr , 25mg/kg daily in divided doses ; 1-6yr, 250mg twice daily; over 6yr, 500mg twice daily. Upper Respiratory Infection : Children : 15mg/kg every 12 hr or 30mg/kg daily . Urinary Tract Infections : Children : 15mg/kg every 12hr. Skin Infections : Children : 15mg/kg every 12hr ( or 30mg/kg once daily for impetigo) .
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
In patients with known or suspected renal impairment, careful clinical observation and appropriate laboratory studies should be made prior to and during the therapy.
Before starting therapy, check the hypersensitivity reaction to cefadroxil, cephalosporins and penicillins. If an allergic reaction occurs, discontinue the drug .
Prolonged use of Cefadroxil may result in overgrowth of non-susceptible organisms.
Careful observation of the patients is essential if super infection occurs during the therapy, appropriate measures should be taken.
Always consult your physician before using any medicine.
Loop diuretics , anticoagulants , other antibiotics , antiplatelets , colestyramine.
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