Meronem 500Mg Iv Injection 1Vial
Brand : pfizer laboratories
Per pc
Rs. 1553.08
Rs. 1634.82
How it works
Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs). Meropenem binds to PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
Description
MERONEM INJ 500 MG 1 VIAL
Generics
Meropenem
used for
Bacterial Infection
Requires Prescription (YES/NO)
Yes
Indication
Meropenem I.V is indicated for the treatment of the following infections in : Adults and children over 3 months of age: • Severe pneumonia including hospital and ventilator-associated pneumonia • Broncho-pulmonary infections in cystic fibrosis • Complicated urinary tract infection • Complicated intra-abdominal infections • Intra- and post-partum infection • Complicated skin and soft tissue infections • Septicemia • Management of febrile neutropenia • Acute bacterial meningitis.
Side Effects
Common : Thrombocythemia, headache, diarrhea, vomiting, nausea, abdominal pain, increased transaminases, increased blood alkaline phosphatase, increased blood lactate dehydrogenase, rash, pruritis, inflammation and pain.Uncommon : Oral and vaginal candidiasis, eosinophilia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, hemolytic anemia, angioedema, anaphylaxis, paraesthesiae, antibiotic-associated colitis, increased blood bilirubin, urticaria, toxic epidermal necrolysis, Stevens Johnson syndrome, erythema multiforme, increased blood creatinine & urea, thrombophlebitis and pain at the injection site.Rare : Convulsions.
When not to Use
Meropenem is contraindicated in patients:- With known hypersensitivity to meropenem or to any excipient of the product.- Hypersensitive to any other carbapenem antibacterial agent.- Who have demonstrated anaphylactic reactions to any other type of ß-lactams antibacterial agent (e.g. Penicillins or cephalosporins).
Dosage
Adults : 500mg - 1gm by IV Bolus inj over 5 min or by IV infusion over 15-30min every 8hr. The dose of Meropenem I.V administered and the duration of treatment should take into account the type of infection to be treated, including its severity and the clinical response. A dose of up to 2g three times daily in adults and adolescents and a dose of up to 40mg/kg three times daily in children may be particularly appropriate when treating some types of infections, such as infections due to less susceptible bacterial species (e.g. Enterobacteriaceae, Pseudomonas aeruginosa or Acinetobacter spp.) or very severe infections.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Precautions
The selection of meropenem to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria.
Warning 1
As with all beta-lactam antibiotics, serious and occasionally fatal hypersensitivity reactions have been reported. Before initiating therapy with meropenem, careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. If a severe allergic reaction occurs, meropenem should be discontinued and appropriate measures should be taken.
Warning 2
Seizures have infrequently been reported during treatment with carbapenems, including meropenem.
Warning 3
Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis).
Pregnancy category
Always consult your physician before using any medicine.
Drug Interactions
Probenecid , Valproic Acid , Oral Anti-coagulants.
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