Onato 5Mg Tablets 20S (Pack Size 2 X 10S)
Brand : sami pharm (pvt) ltd.
How it works
The mechanism of the antihypertensive action of amlodipine is due to direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles thus, reduces the total peripheral resistance (after load) against which the heart works.
ONATO TAB 5 MG 2X10'S
Requires Prescription (YES/NO)
Amlodipine Besylate is indicated for the first line treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients.Amlodipine Besylate is indicated for the first line treatment of myocardial ischemia whether due to fixed obstruction (stable angina) and/ or vasospasm/vasoconstriction (prinzmetal’s or variant angina) of coronary vasculature.
Amlodipine Besylate is well tolerated; the most commonly observed side effects were headache, edema, fatigue, nausea, flushing and dizziness.
When not to Use
Amlodipine Besylate is contraindicated in patients with a known hypersensitivity to dihydropyridines.
Adults : For both hypertension and angina, the usual initial dose is 5mg amlodipine once daily which may be increased to a maximum dose of 10mg depending on the individual patient’s response. Children : Under 6yr , not recommended. Hypertension : 6-12yr, initially 100-200mcg/kg once daily; if necessary increase at intervals of 1-2wk upto 400mcg/kg once daily; max. 10mg once daily; 12-18yr, initially 5mg once daily; if necessary increase at intervals of 1-2wk to max 10mg once daily. Always consult with your your doctor or pharmacist for dose adjustments.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Amlodipine Besylate used at similar doses in elderly or younger patients, is equally well tolerated. Therefore, normal dosage regimens are recommended.
Changes in Amlodipine Besylate plasma concentrations are not correlated with degree of renal impairment. Amlodipine Besylate may be used in such patients at normal doses.
Amlodipine Besylate half life is prolonged in patients with impaired liver function, the drug should therefore be administered with caution in these patients.
Safety of Amlodipine Besylate in human pregnancy or lactation has not been established.
Always consult your physician before using any medicine.
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