P-Doxime Iv/Im Specification
Requires Prescription (YES/NO)
Yes
Generics
Pralidoxime Chloride
Used For
Antidote
How it works
The principal action of pralidoxime chloride is to reactivate cholinesterase (mainly outside of the central nervous system) which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound. The destruction of accumulated acetylcholine can then proceed, and neuromuscular junctions will again function normally. Pralidoxime chloride also slows the process of “aging” of phosphorylated cholinesterase to a nonreactivatable form, and detoxifies certain organophosphates by direct chemical reaction. The drug has its most critical effect in relieving paralysis of the muscles of respiration. Because pralidoxime chloride is less effective in relieving depression of the respiratory center, atropine is always required concomitantly to block the effect of accumulated acetylcholine at this site. Pralidoxime chloride relieves muscarinic signs and symptoms, salivation, bronchospasm, etc., but this action is relatively unimportant since atropine is adequate for this purpose .
P-Doxime Iv/Im Usage And Safety
Dosage
Pralidoxime Chloride
Side Effects
Blurred vision, diplopia and impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia, increased systolic and diastolic blood pressure, hyperventilation and muscular weakness.
Drug Interactions
Atropine , morphine, theophylline, aminophylline, reserpine, and phenothiazine-type tranquilizers .
Indication
It is indicated as an antidote: (1) In the treatment of poisoning due to those pesticides and chemicals (e.g., nerve agents) of the organophosphate class which have anticholinesterase activity and (2) In the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.
When not to Use
Relative contraindications include known hypersensitivity to the drug and other situations in which the risk of its use clearly outweighs possible benefit.
P-Doxime Iv/Im Precautions
Precaution
It should be used with great caution in treating organophosphate overdosage in cases of myasthenia gravis since it may precipitate a myasthenic crisis.
P-Doxime Iv/Im Warnings
Warning 1
It is not indicated as an antidote for intoxication by pesticides of the carbamate class since it may increase the toxicity of carbaryl.
Warning 2
It is not effective in the treatment of poisoning due to phosphorus, inorganic phosphates, or organophosphates not having anticholinesterase activity.
Warning 3
Because pralidoxime is excreted in the urine, a decrease in renal function will result in increased blood levels of the drug. Thus, the dosage of Pralidoxime Chloride should be reduced in the presence of renal insufficiency.
P-Doxime Iv/Im Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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