Pirexen 20 Mg 2X10 Tablets
Brand : saffron pharmaceutical comp
How it works
Piroxicam an NSAID complex with cyclodextrin, possess analgesic and antipyretic properties, the complex allows single molecule of NSAID to be released adjacent to the gastrointestinal mucosa, instead of crystals. Since the time contact with gastric mucosa is reduced, the risk of direct contact gastric irritation is also reduced.
PIREXEN TAB 20 MG 2X10'S
Piroxicam beta cyclodextrin
Pain & Inflammation
Requires Prescription (YES/NO)
It is indicated for a variety of acute painful conditions requiring anti-inflammatory and analgesic activity, including rheumatoid arthritis, osteo-arthritis (arthrosis, degenerative joint disease), ankylosing spondylitis, musculoskeletal and joint disorders, gout, in soft-tissue disorders and in post-operative pain.
Very common: Nausea, epigastric distress, abdominal pain and discomfort, flatulence, constipation and diarrhea. Other possible reactions are hypersensitivity signs, such as skin rash, headache, vertigo, asthenia, blood chemistry modifications, and increase in blood urea. Less common: Vomiting, allergic oedema of the face and hands, blurred vision, tinnitus, aplastic anaemia, leucopoenia, eosinophilia, pancytopenia, thrombocytopenia, increase in parameters of liver functions, jaundice, acute renal insufficiency, water retention that may occur in the form of edema (mainly ankle edema), or cardiocirculatory disorders hypertension, congestive heart failure). Sporadic cases of gastric ulcer with perforation, Stevens-Johnson's syndrome, Lyell’s syndrome-, agranulocytosis, bladder disorders, shock and warning symptoms, acute heart failure. Stomatitis, alopecia and nail growth disorders have been reported. Rare: Gastric ulcers and hemorrhages may also occur.
When not to Use
Piroxicam should not be used in the following: Known hypersensitivity to the drug. Gastroduodenal ulcer, gastritis, dyspepsia, severe hepatic or renal disturbances, severe heart failure, severe hypertension, severe blood alterations or hemorrhagic diathesis. Piroxicam must not be administered to patients in whom acetylsalicylic acid or other NSAIDs induce the symptoms of asthma, rhinitis or urticaria. Ascertained or suspected pregnancy, during lactation and in children.
Oral : In rheumatic disorders a usual initial dose of this medicine is 20mg daily as a single dose. In acute musculoskeletal conditions an initial dose of 40mg daily may be given for 2 days followed by 20mg daily for a total of 1 to 2 weeks. It is also used in acute gout, the usual dose being 40mg daily for 5 to 7 days. OR As directed by your physician.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Piroxicam should be used with caution in patients with asthma because bronchial smooth muscle spasm may be aggravated by prostaglandin inhibition.
NSAIDs inhibit the synthesis of renal prostaglandin which plays a supportive role in the maintenance of renal perfusion in patients whose renal blood flow and blood volume are decreased.
Serious gastrointestinal toxicity such as bleeding, ulceration and perforation can occur anytime with or without warning symptoms, in patients treated chronically with NSAID therapy. Piroxicam must be used under strict medical control in patients with a medical history of disturbances in the upper gastrointestinal tract.
As with other NSAIDs, piroxicam should be given under close supervision to patients with hypertension as the antihypertensive effect of thiazide diuretics and -blocking agents is antagonized by NSAIDs.
Always consult your physician before using any medicine.
Warfarin , Protein bound drugs , Methotrexate , Aspirin and other NSAIDs , Plasma lithium concentrations , Diuretics , Anti-hypertensives , Cardiac Glycosides , Quinolone Antibiotics , Mifepristone , Cyclosporine , Aminoglycosides , Oral Hypoglycemic Agents.
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