Sandostatin Iv Specification
Requires Prescription (YES/NO)
Yes
Generics
Octreotide Acetate
Used For
Cancer
How it works
Sandostatin (octreotide acetate) Injection exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of growth hormone (GH), glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses luteinizing hormone (LH) response to gonadotropin releasing hormone (GnRH), decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, and pancreatic polypeptide. By virtue of these pharmacological actions, octreotide has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and VIP secreting adenomas (watery diarrhea). Octreotide substantially reduces GH and/or insulin growth factor-1 (IGF-1; somatomedin C) levels in patients with acromegaly. Single doses of octreotide have been shown to inhibit gallbladder contractility and to decrease bile secretion in normal volunteers. In controlled clinical trials, the incidence of gallstone or biliary sludgeformation was markedly increased . Octreotide suppresses secretion of thyroid stimulating hormone (TSH).
Sandostatin Iv Usage And Safety
Dosage
Octreotide Acetate
Side Effects
Inj site reaction , GI disturbances . Gallstones , biliary colic . Rarely , persistent hyperglycaemia , hypoglycaemia , hair loss , hepatic dysfunction , acute pancreatitis .
Drug Interactions
Cyclosporin , cimetidine , bromocriptine .
Indication
Sandostatin Inj 0.05mg/0.1mg : Relief of symptoms associated with gastro-entero-pancreatic endocrine (GEP) tumours, carcinoid tumours . VIPomas and glucagonomas . Prevention of complications following pancreatic surgery . Short-term treatment of acromegaly prior to pituitary surgery . Long-term treatment in whom surgery , dopamine agonists or radiotherapy are ineffective oe inappropriate , or interim period until radiotherapy effective . Sandostatin LAR inj : Relief of symptoms associated with gastro-pancreatic endocrine (GEP) tumours including carcinoid tumours . VIPomas and glucagonomas n patients controlled by subcutaneous sandostatin . Acromegaly in patients controlled by subcutaneous sandostatin in whom surgery , dopamine agonists or radiotherapy are ineffective oe inappropriate , or interim period until radiotherapy becomes ineffective .
When not to Use
Hypersensitive to any of the ingredients in the list.
Sandostatin Iv Precautions
Precaution
Acromegaly may lead to infertility, there are reports of pregnancy in acromegalic women. In women with active acromegaly who have been unable to become pregnant, normalization of GH and IGF-1 (somatomedin C) may restore fertility. Female patients of child-bearing potential should be advised to use adequate contraception during treatment with octreotide.
Sandostatin Iv Warnings
Warning 1
The hypoglycemia or hyperglycemia which occurs during Sandostatin therapy is usually mild, but may result in overt diabetes mellitus or necessitate dose changes in insulin or other hypoglycemic agents. Hypoglycemia and hyperglycemia occurred on Sandostatin in 3% and 16% of acromegalic patients, respectively. Severe hyperglycemia, subsequent pneumonia, and death following initiation of Sandostatin therapy was reported in one patient with no history of hyperglycemia.
Warning 2
Several cases of pancreatitis have been reported in patients receiving Sandostatin therapy.
Warning 3
Sandostatin may alter absorption of dietary fats in some patients
Sandostatin Iv Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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