Sivab Tablets 7.5Mg (1 Strip = 7 Tablets)

Name: Sivab Tablets 7.5Mg (1 Strip = 7 Tablets)
Brand: GETZ PHARMA PAKISTAN
Price: 253.68

Brand : getz pharma pakistan

Rs. 253.68

Rs. 267.00

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Sivab Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

Ivabradine

Used For

Angina

How it works

Ivabradine is a pure heart rate lowering agent, acting by selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarization in the sinus node and regulates heart rate. The cardiac effects are specific to the sinus node with no effect on intra-atrial, atrioventricular or intraventricular conduction times, nor on myocardial contractility or ventricular repolarization.

Sivab Tablets Usage And Safety

Dosage

Ivabradine

Side Effects

The most common adverse effects seen with ivabradine are luminous phenomena in the visual field (Phosphenes). Other adverse reactions include blurred vision, bradycardia, which may be severe and other cardiac arrhythmias, nausea, constipation, diarrhea, headache, dizziness, dyspnea and muscle cramps. Hyperuricemia, eosinophilia and elevated blood creatinine concentrations have been reported.

Drug Interactions

Concomitant use with Cytochrome P450 3A4 (CYP3A4) inhibitor or inducers: CYP3A4 inhibitors increase ivabradine plasma concentrations, while inducers decrease them. Increased plasma concentrations of ivabradine may be associated with a risk of excessive bradycardia.- Moderate CYP3A4 inhibitors (e.g. diltiazem, verapamil) with heart rate reducing properties: Concomitant use of ivabradine with diltiazem and verapamil is not recommended due to the potential for additive heart rate lowering effects.- Other moderate CYP3A4 inhibitors: Ivabradine can be used with caution if resting heart rate is at or above 60 bpm and heart rate is carefully monitored.- Grapefruit Juice: Grapefruit juice increase ivabradine exposure. Therefore, the intake of grapefruit juice should be restricted during the treatment with ivabradine.- CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin, St John's Wort): Prolonged concomitant administration of these agents with ivabradine may decrease ivabradine exposure and therefore require an adjustment of dose depending upon the therapeutic response.Concomitant use with QT-prolonging medicines: The concomitant use of cardiovascular (e.g. quinidine, disopyramide, sotalol, amiodarone) or non-cardiovascular (e.g. tricyclic antidepressants, antipsychotics, erythromycin IV, pentamidine, pimozide, mefloquine) QT prolonging medicines with ivabradine should be avoided since QT prolongation may be exacerbated by heart rate reduction. If combination appears necessary, close cardiac monitoring is needed.Concomitant use with Potassium-depleting diuretics: Hypokalemia can increase the risk of arrhythmia. As ivabradine may cause bradycardia, the resulting combination of hypokalemia and bradycardia is a predisposing factor to the onset of severe arrhythmias, especially in patients with long QT syndrome, whether congenital or substance-induced.

Indication

Coronory Artery Disease (CAD) : Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm:- Who are unable to tolerate or have a contraindication to beta blockers, or- In combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is > 60 bpm . Chronic Heart Failure (CHF) : Symptomatic treatment of chronic heart failure of NYHA Classes II or III and with documented left ventricular ejection fraction (LVEF) = 35% in adult patients in sinus rhythm and with heart rate at or above 77 bpm, in combination with optimal standard chronic heart failure treatment.

When not to Use

Ivabradine is contraindicated in patients with: - Hypersensitivity to ivabradine or to any of the excipient of the product - Resting heart rate below 60 bpm prior to treatment- Cardiogenic shock - Acute myocardial infarction - Severe hypotension (< 90/50 mm/Hg) - Severe hepatic impairment- Sick sinus syndrome - Sino-atrial block - Unstable or acute heart failure - Pacemaker dependent - Unstable angina- AV-block 3rd degree- Combination with strong cytochrome P450 3A4 inhibitors such as azole antifungals (ketoconozole, itraconozole), macrolide antibiotics (clarithromycin, erythromycin, josamycin, telithomycin), HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone. - Pregnancy, nursing mothers and women of child-bearing potential not using appropriate contraceptive measure.

Sivab Tablets Precautions

Precaution

Cardiac arrhythmias: Ivabradine is not recommended in patients with atrial fibrillation or other cardiac arrhythmias that interfere with sinus node function. It is recommended to regularly clinically monitor ivabradine treated patients for the occurrence of atrial fibrillation which should also include ECG monitoring if clinically indicated. The risk of developing atrial fibrillation may be higher in chronic heart failure patients treated with ivabradine. Chronic heart failure patients with intraventricular conduction defects and ventricular dyssynchrony should be monitored closely .

Sivab Tablets Warnings

Warning 1

Low heart rate: If during treatment, resting heart rate decreases persistently below 50 bpm or the patient experiences symptoms related to bradycardia such as dizziness, fatigue or hypotension, the dose must be titrated downward or treatment discontinued if heart rate below 50 bpm or symptoms of bradycardia persist.

Warning 2

Chronic heart failure: Heart failure must be stable before considering ivabradine treatment. Ivabradine should be used with caution in heart failure patients with NYHA functional classification IV .

Warning 3

Hypotension: : Ivabradine should be used with caution in patients with mild to moderate hypotension .

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