Tezox Injection 500Mg

Brand : bosch pharmaceuticals

Rs. 135.85

Rs. 143.00

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SPECIFICATION

Requires Prescription (YES/NO)

Yes

Generics

Ceftizoxime

Used For

Bacterial Infection

How it works

The bactericidal action of Ceftizoxime results from inhibition of cell-wall synthesis. Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases (penicillinase and cephalosporinase), including Richmond types I, II, III, TEM, and IV, produced by both aerobic and anaerobic gram-positive and gram-negative organisms. Ceftizoxime has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections .

USAGE AND SAFETY

Dosage

Ceftizoxime

Side Effects

The most frequent adverse reactions (greater than 1% but less than 5%) are: Hypersensitivity--Rash, pruritus, fever ; Hepatic--Transient elevation in AST (SGOT), ALT (SGPT), and alkaline phosphatase ; Hematologic--Transient eosinophilia, thrombocytosis. Some individuals have developed a positive Coombs test ; Local--Injection site--Burning, cellulitis, phlebitis with IV administration, pain, induration, tenderness, paresthesia. The less frequent adverse reactions (less than 1%) are: Hypersensitivity--Numbness and anaphylaxis have been reported rarely ; Hepatic--Elevation of bilirubin has been reported rarely ; Renal--Transient elevations of BUN and creatinine have been occasionally observed with Cefizox ; Hematologic--Anemia, including hemolytic anemia with occasional fatal outcome, leukopenia, neutropenia, and thrombocytopenia have been reported rarely.

Drug Interactions

Cephalosporins , Aminoglycosides.

Indication

Infections of the lower respiratory tract, skin and soft tissues . Septicaemia. Severe infections in immunocompromised patients . UTI & gonorrhoea.

When not to Use

It is contraindicated in patients who have known allergy to the drug.

PRECAUTIONS

Precaution

As with all broadspectrum antibiotics, ceftizoxime for injection should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis .

WARNINGS

Warning 1

Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of “antibiotic-associated” colitis.

Warning 2

Although Ceftizoxime has not been shown to produce an alteration in renal function, renal status should be evaluated, especially in seriously ill patients receiving maximum dose therapy. As with any antibiotic, prolonged use may result in overgrowth of nonsusceptible organisms. Careful observation is essential; appropriate measures should be taken if superinfection occurs.

Warning 3

Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.