Zenbar 30 Mg 10 Capsules
Brand : searle pakistan (pvt) ltd.
Per Box
Rs. 335.40
Rs. 353.00
How it works
Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.
Description
ZENBAR CAP 30 MG 10'S
Generics
Duloxetine hydrochloride
used for
Depression
Requires Prescription (YES/NO)
Yes
Indication
It is used in depression, anxiety, neuropathic and muscular pain.
Side Effects
GI disorders , excessive sweating CNS disorders e.g. dizziness , fatigue , insomnia , somnolence , blurred vision , dysuria , headache , dry mouth , wt loss , palpitation , tremor , tinnitus , muscle spasms , anorexia, increased libido , anxiety , abnormal dreams.
When not to Use
The use of MAOIs intended to treat psychiatric disorders with duloxetine or within 5 days of stopping treatment with duloxetine is contraindicated because of an increased risk of serotonin syndrome.
Dosage
Adults : Major drepressive disorder : Initial & maintenance dose : 60mg once daily. Generalized anxiety disorders : 30mg daily, increased if necessary to 60mg once daily , max 120mg daily. Diabetic peripheral neuropathic pain : 60mg once daily , max 120mg in divided doses. Children : Not recommended. OR As directed by your physician.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Precautions
Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs.
Warning 1
It should be discontinued in patients who develop jaundice or other evidence of clinically significant liver dysfunction and should not be resumed unless another cause can be established.
Warning 2
Orthostatic hypotension and syncope have been reported with therapeutic doses of duloxetine. Syncope and orthostatic hypotension tend to occur within the first week of therapy but can occur at any time during duloxetine treatment, particularly after dose increases.
Warning 3
Severe skin reactions, including erythema multiforme and Stevens-Johnson Syndrome (SJS), can occur with Duloxetine.
Pregnancy category
Always consult your physician before using any medicine.
Drug Interactions
CYP1A2 Inhibitors , CYP2D6 Inhibitors , tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazine and Type 1C anti-arrhythmic (e.g., propafenone, flecainide), Alcohol.
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