Zolanix Capsules 150Mg - Buy Online at DVAGO®

How it works

Fluconazole is a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole. Fluconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.

Description

ZOLANIX CAP 150 MG 4'S

Generics

Fluconazole

used for

Fungal Infection

Requires Prescription (YES/NO)

Yes

Indication

It is used to treat infections caused by fungi and may also be used to stop you from getting a candidal infection. The most common cause of fungal infections is a yeast called Candida.

Side Effects

Common side effects (may affect up to 1 in 10 people) are: - Headache - stomach discomfort, diarrhoea, feeling sick, vomiting - increases in blood tests of liver function - rash . Uncommon side effects (may affect up to 1 in 100 people) are: - Reduction in red blood cells which can make skin pale and cause weakness or breathlessness - decreased appetite- inability to sleep, feeling drowsy - fit, dizziness, sensation of spinning, tingling, pricking or numbness, changes in sense of taste - constipation, difficult digestion, wind, dry mouth - muscle pain - liver damage and yellowing of the skin and eyes (jaundice) - wheals, blistering (hives), itching, increased sweating - tiredness, general feeling of being unwell, fever.

When not to Use

Do not take - If you are allergic to fluconazole, to other medicines you have taken to treat fungal infections or to any of the other ingredients of this medicine . The symptoms may include itching, reddening of the skin or difficulty in breathing - If you are taking astemizole, terfenadine (antihistamine medicines for allergies) - If you are taking cisapride (used for stomach upsets) .

Dosage

Vaginal candidiasis and candidal balanitis : Adults : Orally, a single dose of 150mg. Mucosal candidiasis ( except genital ) : Adults : Orally, 50mg daily ( 100mg daily in unusually difficult infections ) given for 7-14 days in oropharyngeal candidiasis ( max 14 days except in severely immunocompromised patients ) ; for 14 days in atrophic oral candidiasis associated with dentures for 14-30 days in other mucosal infections ( e.g. oesophagitis, candiduria , non-invasive bronchopulmonary infections). Children : Orally or by IV infusion , 3-6mg/kg on first day then 3mg/kg daily ( every 72 hr in neonates upto 2wk old , every 48hr in neonates of 2-4 wk old ). OR As as directed by your physician.

Storage yes or /no

Store this medicine at room temperature, away from direct light and heat.

Precautions

Serious skin reactions including drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported in association with fluconazole treatment. Stop taking and seek medical attention immediately if you notice any of the symptoms related to these serious skin reactions.

Warning 1

Fluconazole should be administered with caution to patients with renal dysfunction .

Warning 2

Fluconazole have been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex or age of patient has been observed. Fluconazole hepatotoxicity has usually been reversible on discontinuation of therapy.

Warning 3

Fluconazole should be administered with caution to patients with potentially proarrhythmic conditions. Coadministration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4 are contraindicated.

Pregnancy category

Always consult your physician before using any medicine.

Drug Interactions

Rifampicin or rifabutin- alfentanil, fentanyl - amitriptyline, nortriptyline - amphotericin B, voriconazole - warfarin or similar medicines - benzodiazepines (midazolam, triazolam or similar medicines) - carbamazepine, phenytoin - nifedipine, isradipine, amlodipine, verapamil, felodipine and losartan (for hypertension- olaparib - ciclosporin, everolimus, sirolimus or tacrolimus - cyclophosphamide, vinca alkaloids (vincristine, vinblastine or similar medicines)- halofantrine- statins (atorvastatin, simvastatin and fluvastatin or similar medicines) - methadone - celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac (NonSteroidal Anti-Inflammatory Drugs (NSAID)) - oral contraceptives - prednisone (steroid) - zidovudine, also known as AZT; saquinavir (used in HIV-infected patients) -chlorpropamide, glibenclamide, glipizide or tolbutamide - theophylline - tofacitinib - tolvaptan used to treat hyponatremia- vitamin A (nutritional supplement) - ivacaftor - amiodarone - hydrochlorothiazide (a diuretic) - ibrutinib .

Zolanix 150Mg Capsules 4S (Pack Size 1 X 4S)

Brand : glaxo smith kline pakistan

Per Box

Rs. 623.24

Rs. 656.06

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