Zestoretic Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Lisinopril Dihydrate , Hydrochlorothiazide
Used For
Hypertension
How it works
Lisinopril : The mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension. Hydrochlorothiazide : The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not usually affect normal blood pressure. Hydrochlorothiazide is a diuretic and antihypertensive. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity increase in aldosterone secretion, increases in urinary potassium loss and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics .
Zestoretic Tablets Usage And Safety
Dosage
Lisinopril Dihydrate , Hydrochlorothiazide
Side Effects
Common : Dizziness, headache, dry cough, fatigue, hypotension including orthostatic hypotension. Small decreases in hemoglobin and haematocrit. Less Common : Diarrhea, nausea, vomiting, dry mouth, rash, gout, palpitations, chest discomfort, muscle cramps and weakness, paraesthesia, asthenia and impotence, hyperglycemia, hyperuricemia and hyper or hypokalemia. Rarely : Pancreatitis, agranulocytosis, elevations of liver enzymes and/or serum bilirubin.
Drug Interactions
Agents Increasing Serum Potassium , Agents Affecting Sympathetic Activity , Lithium , Corticosteroids (ACTH) , Nonsteroidal Anti-inflammatory Drugs , Tubocurarine , Insulin , Alcohol, Barbiturates or Narcotics , Pressor Amines .
Indication
It is indicated in the management of mild to moderate hypertension in patients who are not adequately controlled on monotherapy.
When not to Use
Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. - Lisinopril+Hydrochlorothiazide is contraindicated in patients who are hypersensitive to other sulphonamide-derived drugs. - Lisinopril+Hydrochlorothiazide is contraindicated in patients with anuria. - Lisinopril+Hydrochlorothiazide is contraindicated in pregnancy and treatment should be stopped if pregnancy is suspected.
Zestoretic Tablets Precautions
Precaution
As with all antihypertensive therapy, symptomatic hypotension may occur in some patients. Periodic determination of serum electrolytes should be performed at appropriate intervals in such patients. In patients at increased risk of symptomatic hypotension, initiation of therapy and dose adjustment should be monitored under close medical supervision .
Zestoretic Tablets Warnings
Warning 1
Particular consideration should be given when therapy is administered to patients with ischemic heart or cerebrovascular disease because an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident.
Warning 2
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Warning 3
Thiazides may decrease urinary calcium excretion and may cause intermittent and slight elevation of serum calcium. Thiazides should be discontinued before carrying out tests for parathyroid function .
Zestoretic Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
Related Products
Rs. 385.77
Rs. 406.07
Rs. 246.96
Rs. 259.98
masdipine sr 30mg tablets 20s (pack size 2x10s)
Rs. 228.00
Rs. 240.00
Rs. 345.80
Rs. 364.00
Rs. 437.08
Rs. 460.00
Rs. 466.76
Rs. 491.45
Rs. 411.60
Rs. 433.22
Rs. 399.00
Rs. 420.00
Rs. 617.54
Rs. 650.00
Rs. 427.56
Rs. 450.00
Rs. 492.10
Rs. 518.01
Rs. 655.50
Rs. 690.00
Rs. 295.40
Rs. 311.00
Rs. 421.82
Rs. 444.00
Rs. 385.70
Rs. 406.00
Rs. 372.40
Rs. 392.01
Rs. 29.10
Rs. 30.62
Rs. 115.40
Rs. 121.54
Rs. 125.60
Rs. 132.20
Rs. 302.90
Rs. 318.89
Rs. 36.10
Rs. 38.03
Rs. 41.30
Rs. 43.50
Rs. 340.80
Rs. 358.76
Rs. 485.00
Rs. 510.44
Rs. 196.65
Rs. 207.00
Rs. 850.92
Rs. 895.70
Rs. 409.50
Rs. 431.06
Rs. 435.70
Rs. 458.67
Rs. 209.02
Rs. 220.00
Rs. 280.28
Rs. 295.00
Rs. 350.70
Rs. 369.15
Rs. 185.29
Rs. 195.02
Rs. 179.55
Rs. 189.00
Rs. 128.24
Rs. 135.00
Rs. 418.04
Rs. 440.00
Rs. 285.04
Rs. 300.02
Rs. 170.94
Rs. 180.00
exforge hct tablets 10mg/320mg/25mg
Rs. 2,108.96
Rs. 2,220.00
Rs. 389.90
Rs. 410.40
Rs. 461.00
Rs. 485.30
Rs. 307.50
Rs. 323.66
avsar plus tablets 160mg/10mg/12.5mg
Rs. 112.84
Rs. 118.75
avsar plus tablets 160mg/5mg/25mg
Rs. 106.89
Rs. 112.50
avsar plus tablets 160mg/5mg/12.5mg
Rs. 403.76
Rs. 425.04
Rs. 389.90
Rs. 410.40
Rs. 272.93
Rs. 287.28
Rs. 287.00
Rs. 302.10
Rs. 394.24
Rs. 415.00
Rs. 304.99
Rs. 321.01
Rs. 250.74
Rs. 263.97
sofvasc hct tablets 10/160/25mg
Rs. 256.76
Rs. 270.29
sofvasc hct tablets 10/160/12.5mg
Rs. 253.96
Rs. 267.26
sofvasc hct tablets 5/160/12.5mg
Rs. 234.22
Rs. 246.54
Rs. 232.75
Rs. 245.00
Rs. 157.30
Rs. 165.60
Rs. 81.48
Rs. 85.75
triforge tablets 10/160/12.5 mg
Rs. 352.52
Rs. 371.01
Rs. 89.32
Rs. 94.00
Rs. 99.80
Rs. 105.00
Rs. 29.96
Rs. 31.50
Rs. 95.30
Rs. 100.33
Rs. 221.00
Rs. 232.66
Rs. 148.54
Rs. 156.40
Rs. 266.60
Rs. 280.60
Rs. 298.06
Rs. 313.68
sarcol - h 50/12.5 tablets 50/12.5 mg
Rs. 399.80
Rs. 420.83
Rs. 583.52
Rs. 614.28
Rs. 344.54
Rs. 362.60
Rs. 106.40
Rs. 112.00
Rs. 209.86
Rs. 220.92
Rs. 152.00
Rs. 160.00
Rs. 89.40
Rs. 94.12
Rs. 413.40
Rs. 435.00
Rs. 321.02
Rs. 337.90
Rs. 478.52
Rs. 503.73
Rs. 321.02
Rs. 337.90
Rs. 388.50
Rs. 408.94
valmo 10/160mg tablets 14s (pack size 1x14s)
Rs. 627.34
Rs. 660.39
Rs. 78.10
Rs. 82.20
Rs. 68.20
Rs. 71.83
Rs. 103.80
Rs. 109.30
Rs. 152.00
Rs. 159.99
exforge hct tablets 5/160/25mg
Rs. 1,018.92
Rs. 1,072.54
exforge hct tablets 10/160/12.5mg
Rs. 1,533.98
Rs. 1,614.65
Rs. 313.46
Rs. 330.00
Rs. 456.00
Rs. 480.00
Rs. 237.50
Rs. 250.00
exforge hct tablets 5/160/12.5mg
Rs. 1,428.14
Rs. 1,503.27
Rs. 375.76
Rs. 395.50
Rs. 260.90
Rs. 274.62
Rs. 522.50
Rs. 550.00
Rs. 252.70
Rs. 266.00
exforge hct tablets 10/160/25mg
Rs. 1,541.54
Rs. 1,622.63
Rs. 294.50
Rs. 310.00
Rs. 969.00
Rs. 1,020.00
Rs. 303.24
Rs. 319.20
Rs. 320.53
Rs. 337.40
Rs. 394.24
Rs. 414.96
Rs. 204.26
Rs. 215.00
Rs. 214.40
Rs. 225.71
Rs. 1,254.26
Rs. 1,320.31
Rs. 1,264.62
Rs. 1,331.14
Rs. 843.08
Rs. 887.44
Rs. 234.70
Rs. 247.00
Rs. 608.02
Rs. 640.08
Rs. 330.68
Rs. 348.04
Rs. 2,871.40
Rs. 3,022.60
coversyl plus tablets 4/1.25mg
Rs. 447.50
Rs. 471.07
Rs. 209.00
Rs. 220.00
Rs. 304.00
Rs. 320.00
Rs. 1,760.64
Rs. 1,853.38
Rs. 617.54
Rs. 650.00
Rs. 146.00
Rs. 153.68
Rs. 190.00
Rs. 200.00
Rs. 242.27
Rs. 255.00
Rs. 358.61
Rs. 377.50
Rs. 243.90
Rs. 256.70
Rs. 412.30
Rs. 434.00
Rs. 184.94
Rs. 194.60
Rs. 359.10
Rs. 378.00
Rs. 133.30
Rs. 140.28
Rs. 104.80
Rs. 110.37
Rs. 3,356.92
Rs. 3,533.60
Rs. 425.32
Rs. 447.71
Rs. 408.52
Rs. 430.00
Rs. 122.30
Rs. 128.75
Rs. 142.50
Rs. 150.00
Rs. 283.20
Rs. 298.11
Rs. 381.90
Rs. 402.00
Rs. 494.60
Rs. 520.68
Rs. 432.00
Rs. 454.71
Rs. 133.00
Rs. 140.00
Rs. 706.60
Rs. 743.75
Rs. 104.50
Rs. 110.00
Rs. 125.70
Rs. 132.32
Rs. 116.40
Rs. 122.51
Rs. 3,167.92
Rs. 3,334.60
Rs. 537.18
Rs. 565.49
Rs. 333.50
Rs. 351.00
Rs. 822.50
Rs. 865.80
Rs. 592.76
Rs. 624.00
Rs. 467.46
Rs. 492.00
Rs. 1,008.56
Rs. 1,061.58
Rs. 306.88
Rs. 323.00
Rs. 104.50
Rs. 110.00
Rs. 189.98
Rs. 200.00
Rs. 139.30
Rs. 146.67
Rs. 586.60
Rs. 617.50
Rs. 190.00
Rs. 200.00
Rs. 147.50
Rs. 155.25
Rs. 215.80
Rs. 227.13
Rs. 448.90
Rs. 472.55
Rs. 389.60
Rs. 410.13
Rs. 200.50
Rs. 211.00
Rs. 72.90
Rs. 76.75
Rs. 883.47
Rs. 930.00
Rs. 308.49
Rs. 324.74
Rs. 141.96
Rs. 149.42
Rs. 139.20
Rs. 146.50
Rs. 222.00
Rs. 233.70
Rs. 570.08
Rs. 600.04
Rs. 932.40
Rs. 981.60
Rs. 69.40
Rs. 73.00
Rs. 164.36
Rs. 173.03
Rs. 476.84
Rs. 502.00
Rs. 271.00
Rs. 285.29
Rs. 173.30
Rs. 182.40
Rs. 430.50
Rs. 453.15
Rs. 316.40
Rs. 333.00
Rs. 95.00
Rs. 100.00
Rs. 469.42
Rs. 494.06
Rs. 83.90
Rs. 88.28
Rs. 476.70
Rs. 501.84
Rs. 475.30
Rs. 500.36
Rs. 250.20
Rs. 263.33
Rs. 395.20
Rs. 416.05
Rs. 106.40
Rs. 112.00
Rs. 95.00
Rs. 100.00
Rs. 94.40
Rs. 99.37
Rs. 332.50
Rs. 350.00
Rs. 389.50
Rs. 410.00
Rs. 342.00
Rs. 360.00
Rs. 98.80
Rs. 104.00
Rs. 50.50
Rs. 53.17
Rs. 352.70
Rs. 371.24
Rs. 898.80
Rs. 946.20
Rs. 266.00
Rs. 280.00
Rs. 346.64
Rs. 364.84
Rs. 710.50
Rs. 747.88
Rs. 369.60
Rs. 389.00
Rs. 209.02
Rs. 220.00
Rs. 29.70
Rs. 31.23
Rs. 635.18
Rs. 668.57
Rs. 55.10
Rs. 57.96
Rs. 194.88
Rs. 205.15
Rs. 134.50
Rs. 141.50
Rs. 240.38
Rs. 253.00
Rs. 153.02
Rs. 161.00
Rs. 112.80
Rs. 118.75
Rs. 80.80
Rs. 85.00
Rs. 330.26
Rs. 347.71
Rs. 270.76
Rs. 285.00
Rs. 218.00
Rs. 229.44
Rs. 53.62
Rs. 56.42
Rs. 94.99
Rs. 100.00
Rs. 189.98
Rs. 200.00
Rs. 249.41
Rs. 262.50
Rs. 663.00
Rs. 697.99
Rs. 74.00
Rs. 77.92
Rs. 191.80
Rs. 201.87
Rs. 437.00
Rs. 460.00
Rs. 522.50
Rs. 550.00
Rs. 235.30
Rs. 247.67
Rs. 222.04
Rs. 233.70
Rs. 247.00
Rs. 260.00
Rs. 266.00
Rs. 280.00
Rs. 726.74
Rs. 765.00
Rs. 1,692.32
Rs. 1,781.36
Rs. 1,149.12
Rs. 1,209.60
Rs. 290.70
Rs. 306.00
Rs. 230.40
Rs. 242.50
Rs. 258.86
Rs. 272.50
Rs. 128.17
Rs. 134.89
Rs. 259.42
Rs. 273.03
Rs. 196.84
Rs. 207.20
Rs. 249.41
Rs. 262.50
Rs. 254.50
Rs. 267.90
Rs. 118.80
Rs. 125.00
Rs. 169.50
Rs. 178.43
Rs. 439.74
Rs. 462.85
Rs. 156.52
Rs. 164.80
Rs. 546.60
Rs. 575.36
Rs. 161.56
Rs. 170.03
Rs. 277.50
Rs. 292.12
Rs. 43.89
Rs. 46.20
Rs. 266.00
Rs. 280.00
Rs. 319.20
Rs. 336.00
Rs. 13.30
Rs. 14.00
triforge 10/320/25 mg tablets 28s
Rs. 13.30
Rs. 14.00
Rs. 338.10
Rs. 356.00
Rs. 29.17
Rs. 30.71
Rs. 19.56
Rs. 20.59
Rs. 11.66
Rs. 12.27
Rs. 26.47
Rs. 27.86
Rs. 503.44
Rs. 530.00
Rs. 180.70
Rs. 190.16
Rs. 227.40
Rs. 239.40
Rs. 226.10
Rs. 238.00
Rs. 85.60
Rs. 90.00
Rs. 207.30
Rs. 218.21
Rs. 368.48
Rs. 388.00
Rs. 190.00
Rs. 200.00
Rs. 456.12
Rs. 480.06
Rs. 389.62
Rs. 410.06
Rs. 731.60
Rs. 770.00
Rs. 359.10
Rs. 378.00
triplixam tablets 5/1.25mg 5mg
Rs. 1,083.00
Rs. 1,140.00
Rs. 308.70
Rs. 325.00
Rs. 684.04
Rs. 720.01
Rs. 250.74
Rs. 263.93
Rs. 152.04
Rs. 160.02
Rs. 484.54
Rs. 510.00
Rs. 417.06
Rs. 439.02
Rs. 425.60
Rs. 448.00
Rs. 308.28
Rs. 324.54
Rs. 41.40
Rs. 43.46
valtec amh tablets 5/160/12.5 mg
Rs. 342.16
Rs. 360.08
Rs. 395.10
Rs. 415.80
Rs. 284.97
Rs. 300.00
Rs. 220.00
Rs. 231.62
Rs. 478.80
Rs. 504.00
Rs. 256.50
Rs. 270.00
Rs. 180.53
Rs. 190.00
Rs. 733.32
Rs. 772.00
Rs. 270.76
Rs. 285.00
Rs. 113.00
Rs. 118.90
Rs. 48.60
Rs. 51.18
Rs. 372.40
Rs. 392.00
qsartan plus tablets 50/12.5mg
Rs. 211.10
Rs. 222.19
Rs. 174.80
Rs. 184.00
Rs. 143.90
Rs. 151.50
Rs. 266.00
Rs. 280.00
Rs. 223.23
Rs. 235.00
Rs. 166.25
Rs. 175.00
Rs. 102.60
Rs. 108.00
Rs. 122.80
Rs. 129.28