Anexate Injection 1Mg/10Ml (1 Box = 5 Injection)

Name: Anexate Injection 1Mg/10Ml (1 Box = 5 Injection)
Brand: Martin Dow
Price: 33034.35

Brand : martin dow

Rs. 33,034.35

Rs. 34,773.00

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Anexate Injection Specification

Requires Prescription (YES/NO)

Yes

Generics

Flumazenil

Used For

Anesthesia

How it works

Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in man. Flumazenil does not antagonize the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids.

Anexate Injection Usage And Safety

Dosage

Flumazenil

Side Effects

Vertigo (spinning sensation), headache, agitation, tremor , diplopia (double vision), strabismus (squinting), lacrimation (weeping eye) , hypotension (low blood pressure), orthostatic hypotension (dizziness on standing), nausea (feeling sick) (after operation), vomiting (after operation, particularly if opiates have been used) , sweating , fatigue, injection site pain , anxiety, fear , palpitations (irregular heartbeats), tachycardia or bradycardia (fast or slow heart rate), extrasystole (a premature contraction of the heart) , dyspnoea (breathlessness), cough, nasal congestion .

Drug Interactions

Zopiclone (a type of sleeping pill) , triazolopyridazine , amitriptyline, imipramine or dosulepine .

Indication

• Flumazenil Injection is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in anesthesia and intensive care in the following situations: • Termination of general anesthesia induced and/or maintained with benzodiazepines. • Reversal of benzodiazepine sedation in short diagnostic and therapeutic procedures. • For the diagnosis and/or as an adjunct to supportive measures used for management of deliberate or accidental benzodiazepine overdosage

When not to Use

Flumazenil Injection is contraindicated: • In patients with known hypersensitivity to flumazenil or to benzodiazepines; • In epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. The abrupt suppression of the protective effect of benzodiazepines may induce convulsions in epileptic patients; • In patients who are showing signs of serious cyclic antidepressant overdose • In patients who have been given a benzodiazepine for a potentially life-threatening condition (e.g., intracranial pressure).

Anexate Injection Precautions

Precaution

The dosage of flumazenil should be adjusted carefully in patients suffering from pre-operative anxiety or having a history of chronic or episodic anxiety. In anxious patients, particularly those with coronary heart disease, it is preferable to maintain a degree of sedation throughout the early postoperative period rather than bring about complete arousal.

Anexate Injection Warnings

Warning 1

The primary treatment of patients with serious lung disease who experience serious respiratory depression due to benzodiazepinesshould be given appropriate ventilatory support, rather than administration of flumazenil.

Warning 2

Flumazenil abruptly terminates the effects of benzodiazepines. As a result, sympathetic tone may be increased and thus, cardiac electrical instability enhanced. Consequently, caution is advised when administering Flumazenil Injection to patients with myocardial infarction or cardiac arrhythmias.

Warning 3

Flumazenil Injection should be used with caution in the Intensive Care Unit because of the increased risk of unrecognized benzodiazepine dependence in such settings. Flumazenil may produce convulsions in patients physically dependent on benzodiazepine .

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