Irecon-H Tablets 150/12.5Mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)
Brand : barrett hodgson pakistan
Rs. 294.50
Rs. 310.00
|
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Irecon-H Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Irbesartan , Hydrochlorothiazide
Used For
Hypertension
How it works
Irbesartan : Irbesartan is a potent, orally active, selective angiotensin-II receptor (type AT1) antagonist. It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II. The selective antagonism of the angiotensin-II (AT1) receptors results in increases in plasma renin levels and angiotensin-II levels, and a decrease in plasma aldosterone concentration. Serum potassium levels are not significantly affected by irbesartan alone at the recommended doses. Irbesartan does not inhibit ACE (kininase-II), an enzyme which generates angiotensin-II and also degrades bradykinin into inactive metabolites. Irbesartan does not require metabolic activation for its activity. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. The mechanism of antihypertensive effect of thiazide diuretic is not fully known. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium. Presumably through blockade of the renin-angiotensin-aldosterone system, co-administration of irbesartan tends to reverse the potassium loss associated with these diuretics. With hydrochlorothiazide, onset of diuresis occurs in 2 hours, and peak effect occurs at about 4 hours, while the action persists for approximately 6-12 hours.
Irecon-H Tablets Usage And Safety
Dosage
Irbesartan , Hydrochlorothiazide
Side Effects
Cardiac disorders: Common: increases in blood urea nitrogen (BUN), creatinine and creatine kinase Uncommon: decreases in serum potassium and sodium .Uncommon: syncope, hypotension, tachycardia, oedema.Nervous system disorders: Common: dizziness Uncommon: orthostatic dizziness Not known: headache . Ear and labyrinth disorders: Not known: tinnitus. Respiratory, thoracic and mediastinal disorders: Not known: cough. Gastrointestinal disorders: Common: nausea/vomiting , Uncommon: diarrhoea , Not known: dyspepsia, dysgeusia .
Drug Interactions
Irbesartan : Lithium , kaliuretic diuretics, laxatives, amphotericin, carbenoxolone, penicillin G sodium , heparin sodium , digitalis glycosides, antiarrhythmics , selective COX-2 inhibitors, acetylsalicylic acid , Hydrochlorothiazide: Thiazide diuretics , Alcohol , Antidiabetic medicinal products (oral agents and insulins) , Colestyramine and Colestipol resins , Corticosteroids, ACTH , Digitalis glycoside , Pressor amines (e.g. noradrenaline) , tubocurarine , probenecid or sulfinpyrazone , calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) , Carbamazepine , atropine, beperiden , cyclophosphamide, methotrexate.
Indication
• Treatment of essential hypertension. • This fixed dose combination is indicated in adult patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone. • It may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals .
When not to Use
• Hypersensitivity to the active substances or to any of the excipients or to other sulfonamide-derived substances (hydrochlorothiazide is a sulfonamide-derived substance)• Second and third trimesters of pregnancy.• Severe renal impairment (creatinine clearance <30 ml/min).• Refractory hypokalaemia, hypercalcaemia.• Severe hepatic impairment, biliary cirrhosis and cholestasis.• The concomitant use of Irbesartan/Hydrochlorothiazide with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (creatinine clearance <60ml/min/1.73 m²).• Due to its HCT component Irbesartan/HCT tablets are contraindicated in anuric patients
Irecon-H Tablets Precautions
Precaution
It has been rarely associated with symptomatic hypotension in hypertensive patients without other risk factors for hypotension. Symptomatic hypotension may be expected to occur in patients who are volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhea or vomiting. Such conditions should be corrected before initiating therapy with Irbesartan/Hydrochlorothiazide.
Irecon-H Tablets Warnings
Warning 1
There is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists. While this is not documented with Irbesartan/Hydrochlorothiazide , a similar effect should be anticipated.
Warning 2
Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system. Therefore, the use of Irbesartan/Hydrochlorothiazide is not recommended.
Warning 3
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Irbesartan/HCT must not be used in patients with severe hepatic impairment. No dosage adjustment is required in patients with mild to moderate hepatic impairment.
Irecon-H Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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Rs. 280.00
ramipace tablets 5mg (1 strip = 14 tablets)
Rs. 407.54
Rs. 429.00
zestril tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 424.76
Rs. 447.18
monitor tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 209.02
Rs. 220.00
merol tablets 25mg (1 strip = 10 tablets)
Rs. 34.20
Rs. 36.03
tritace tablets 10mg (1 strip = 14 tablets)
Rs. 635.18
Rs. 668.57
merol tablets 50mg (1 strip = 10 tablets)
Rs. 63.30
Rs. 66.67
inderal tablets 40mg (1 bottle = 50 tablets)
Rs. 277.50
Rs. 291.94
valam tablets 5mg/80mg (1 strip = 7 tablets)
Rs. 214.41
Rs. 225.68
inderal tablets 10mg (1 bottle = 50 tablets)
Rs. 147.50
Rs. 155.38
valtec tablets 80mg (1 strip = 14 tablets)
Rs. 240.38
Rs. 253.00
diovan tablets 160mg (1 strip = 14 tablets)
Rs. 1,401.26
Rs. 1,475.00
valtec tablets 40mg (1 strip = 14 tablets)
Rs. 153.02
Rs. 161.00
avsar tablets 5/80mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 399.00
Rs. 420.00
onato tablets 5mg (1 strip = 10 tablets)
Rs. 80.80
Rs. 85.00
treatan tablets 8mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 353.36
Rs. 372.00
treatan tablets 4mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 289.80
Rs. 305.00
tansin tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 218.00
Rs. 229.44
nebil tablets 2.5mg (1 strip = 7 tablets)
Rs. 106.89
Rs. 112.50
advant tablets 8mg (1 strip = 7 tablets)
Rs. 218.47
Rs. 230.00
advant tablets 16mg (1 strip = 7 tablets)
Rs. 287.35
Rs. 302.50
sofvasc tablets 10mg (1 box = 2 strips) (1 strip = 15 tablets)
Rs. 663.00
Rs. 697.99
corace tablets 5mg (1 strip = 10 tablets)
Rs. 74.00
Rs. 77.92
zestril tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 220.50
Rs. 232.15
amtas tablets 5mg+40mg (1 strip = 7 tablets)
Rs. 192.85
Rs. 203.00
sartan tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 332.50
Rs. 350.00
olesta tablets 40mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 364.60
Rs. 383.75
irecon tablets 75mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 190.00
Rs. 200.00
olesta tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 264.40
Rs. 278.28
co-renitec tablets 10mg/25mg (1 strip = 10 tablets)
Rs. 235.30
Rs. 247.67
telsan tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 247.00
Rs. 260.00
omsana tablets 40mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 726.74
Rs. 765.00
omsana tablets 20mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 491.26
Rs. 517.16
diovan tablets 80mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 2,042.60
Rs. 2,150.00
byscard tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 420.00
Rs. 442.04
tritace tablets 5mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 1,149.12
Rs. 1,209.60
carlov tablets 25mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 311.10
Rs. 327.42
lame tablets 10mg (1 strip = 15 tablets)
Rs. 230.40
Rs. 242.50
calan tablets 80mg (1 bottle = 50 tablets)
Rs. 235.50
Rs. 247.64
calan tablets 40mg (1 bottle = 50 tablets)
Rs. 172.50
Rs. 181.80
tasmi tablets 80mg (1 strip = 7 tablets)
Rs. 284.97
Rs. 300.00
tasmi tablets 20mg (1 strip = 7 tablets)
Rs. 136.99
Rs. 144.18
actim tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 259.42
Rs. 273.03
tasmi tablets 40mg (1 strip = 7 tablets)
Rs. 210.42
Rs. 221.48
advantec tablets 16mg+12.5mg (1 strip = 14 tablets)
Rs. 569.94
Rs. 600.00
xavor tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 254.50
Rs. 267.90
sofvasc tablets 5mg (1 strip = 15 tablets)
Rs. 169.50
Rs. 178.43