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      Dvago

      Piozer Tablets 30Mg

      Rs. 249.41

      Rs. 262.50

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      QUICK DELIVERY

      SPECIFICATION

      Requires Prescription (YES/NO)

      Yes

      Generics

      Pioglitazone HCl

      Used For

      Diabetes

      How it works

      Pioglitazone is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPAR?). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR? nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.

      USAGE AND SAFETY

      Dosage

      Pioglitazone HCl

      Side Effects

      Very Common : Hypoglycaemia, edema.Common : Visual disturbances, upper respiratory tract infection, weight increase, hypoaesthesia, anemia, arthralgia, headache, haematuria, erectile dysfunction, flatulence, dizziness, blood creatine phosphokinase increase, bronchitis, back pain, dyspnoea, heart failure.Rare : Sinusitis, flatulence, vertigo, fatigue, increased lactic dehydrogenase, appetite increased, hypoglycaemia, headache, glycosuria, proteinuria, sweating.

      Drug Interactions

      Midazolam , Gemfibrozil , Rifampicin.

      Indication

      It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

      When not to Use

      Pioglitazone is contraindicated in patients with: • Hypersensitivity to the active substance or to any of the excipients. • Cardiac failure or history of cardiac failure (NYHA stages I to IV). • Hepatic impairment • Diabetic ketoacidosis.

      PRECAUTIONS

      Precaution

      Pioglitazone exerts its antihyperglycemic effect only in the presence of insulin. Therefore, pioglitazone should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.

      WARNINGS

      Warning 1

      Patients receiving pioglitazone in combination with insulin or oral hypoglycemic agents may be at risk for hypoglycemia, and a reduction in the dose of the concomitant agent may be necessary.

      Warning 2

      Pioglitazone may cause decreases in hemoglobin and hematocrit.

      Warning 3

      Dose related weight gain may occur with pioglitazone alone and in combination with other hypoglycemic agents.

      ADDITIONAL INFORMATION

      Pregnancy category

      Always consult your physician before using any medicine.

      Storage (YES/NO)

      Store this medicine at room temperature, away from direct light and heat.

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