Synflex-M Tablets 85Mg+550Mg (1 Box = 1 Strip)(1 Strip = 2 Tablets)

Name: Synflex-M Tablets 85Mg+550Mg (1 Box = 1 Strip)(1 Strip = 2 Tablets)
Brand: Martin Dow
Price: 380

Brand : martin dow

Rs. 380.00

Rs. 400.00

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Synflex-M Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

Naproxen Sodium , Sumatriptan

Used For

Migraine

How it works

It contains sumatriptan, a 5-HT1 receptor agonist that mediates vasoconstriction of the human basilar artery and vasculature of human dura mater, which correlates with the relief of migraine headache. It also contains naproxen, an NSAID that inhibits the synthesis of inflammatory mediators. Therefore, sumatriptan and naproxen contribute to the relief of migraine through pharmacologically different mechanisms of action.

Synflex-M Tablets Usage And Safety

Dosage

Naproxen Sodium , Sumatriptan

Side Effects

Cardiac disorders: Chest pain . Gastrointestinal disorders: Diarrhea, dysgeusia, flatulence . General disorders: Asthenia, feeling hot, fatigue, feeling abnormal, lethargy . Metabolism and nutrition disorders: Thirst . Musculoskeletal and connective tissue: Neck pain, pain in jaw, muscular weakness, musculoskeletal stiffness, myalgia. Nervous system disorders: Tremor, burning sensation, headache, hyperesthesia, vertigo . Psychiatric disorders: Anxiety . Respiratory, thoracic and mediastinal: Nasal passage irritation, pharyngolaryngeal pain . Skin: hyperhidrosis . Vascular disorders: flushing.

Drug Interactions

Sumitriptan : Ergot-type medications (like dihydroergotamine or methysergide) , MAO Inhibitors , Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) and triptans , Other 5-HT1 agonists . Naproxen Sodium : ASA and ibuprofen , Antacids , Anti-coagulants , Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) , Beta-blockers , Albumin Bound Drugs , Anti-platelet Agents (including ASA) , Cholestyramine , Cyclosporin , Digoxin , Diuretics , Glucocorticoids , Lithium , Methotrexate , Probenecid.

Indication

For treatment of acute migraine.

When not to Use

It is contraindicated in : Known hypersensitivity (e.g., anaphylactic reactions, angioedema, and serious skin reactions) to sumatriptan, naproxen sodium, or any component . - Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or coronary artery vasospasm, including Prinzmetal’s angina .

Synflex-M Tablets Precautions

Precaution

Sumatriptan, a component of this medicine, can cause coronary artery vasospasm. It is contraindicated in patients with uncontrolled hypertension, ischemic coronary artery disease, cardiac arrhythmias, and those with history of myocardial infarction .

Synflex-M Tablets Warnings

Warning 1

Naproxen, a component of this medicine, is a non-steroidal anti-inflammatory drug (NSAID). Use of some NSAIDs is associated with an increased incidence of cardiovascular adverse events (such as myocardial infarction, stroke or thrombotic events) which can be fatal. The risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.

Warning 2

Caution should be exercised in prescribing NSAIDs such as naproxen sodium, which is a component of this medicine to any patient with ischemic heart disease (including but NOT limited to acute myocardial infarction, history of myocardial infarction and/or angina), cerebrovascular disease (including but NOT limited to stroke, cerebrovascular accident, transient ischemic attacks and/or amaurosis fugax) and/or congestive heart failure (NYHA II-IV) .

Warning 3

Overuse of acute headache treatments is associated with the exacerbation of headache (medication overuse headache, MOH). Medication overuse headache may present as migraine-like daily headaches, or as a marked increase in frequency of migraine attacks. In these cases, discontinuation of medication should be considered.

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