Eleva Plus 2 Grams Injection
Brand : wilshire laboratories
How it works
The anti-bacterial component of sulbactam/cefoperazone is cefoperazone, a third generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting biosynthesis of cell wall mucopeptide. Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter. However, biochemical studies with cell-free bacterial systems have shown it to be an irreversible inhibitor of most important beta-lactamases produced by beta-lactam antibiotic-resistant organisms.
ELEVA PLUS 2GM INJ 1'S
Cefoperazone , Salbactam
Requires Prescription (YES/NO)
Monotherapy : It is indicated for the treatment of the following infections when caused by susceptible organisms:i. Respiratory tract infections (upper and lower) ii. Urinary tract infections (upper and lower) iii. Peritonitis, cholecystitis, cholangitis, and other intra-abdominal infections iv. Septicaemia v. Meningitisvi. Skin and soft tissue infections vii. Bone and joint infections viii. Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tractCombination Therapy : Because of the broad spectrum of activity of Sulbactum/ Cefoperazone, most infections can be treated adequately with this antibiotic combination alone. However, Sulbactum/Cefoperazone may also be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function should be monitored during the course of therapy.
Sulbactam/cefoperazone is generally well-tolerated. The majority of adverse events are of mild or moderate severity and are tolerated with continued treatment. The most frequent side effects observed with Sulbactum/Cefoperazone have been gastrointestinal. Others include dermatologic reactions, headache, injection pain, chills, and anaphylactoid reactions.
When not to Use
It is contraindicated in patients with a known allergy to penicillins, sulbactam, cefoperazone, or any of the cephalosporins.
Adults : The usual adult dose of the combination is 2 to 4 g/day (i.e, 1-2 g/day each of Cefoperazone and Sulbactam given IV or IM in equally divided doses every 12 hours. In severe or refractory infections the daily dosage may be increased to 8g (i.e, 4g/day each of Cefoperazone and Sulbactam) given IV in equally divided doses every 12 hours. The recommended maximum daily dosage of Sulbactam is 4g (8g of the combination). Children : The usual dosage in children is 40-80mg/kg/day (20 to 40 mg/kg/day each of Cefoperazone and Sulbactam) every six to twelve hours. In serious or refractory infections, these dosages may be increased upto 240mg/kg/day (160 mg/kg/day cefoperazone activity). Doses should be administered in two to four equally divided doses.Use in Neonates : For neonates in the first week of life, the drug should be given every 12 hours. The maximum daily dosage of sulbactam in paediatrics should not exceed 80 mg/kg/day . Always consult your doctor or pharmacist for dose adjustments.
Storage yes or /no
Store this medicine at room temperature, away from direct light and heat.
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactam or cephalosporin therapy. These reactions are more apt to occur in individuals with a history of hypersensitivity reactions to multiple allergens. If an allergic reaction occurs, the drug should be discontinued and the appropriate therapy instituted.
As with other antibiotics, overgrowth of non-susceptible organisms may occur during the prolonged use of Sulbactum/Cefoperazone. It has not been extensively studied in premature infants or neonates. Therefore, in treating premature infants and neonates, the potential benefits and possible risks involved should be considered before instituting therapy.
If an allergic reaction occurs, the drug should be discontinued and the appropriate therapy instituted.
Before therapy with sulbactam/cefoperazone is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins or other drugs . Antibiotics should be administered with caution to any patient who has demonstrated some form of allergy, particularly to drugs.
Always consult your physician before using any medicine.
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